{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:08:22Z","timestamp":1753888102645,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nature Science Foundation of Hubei Province","award":["2020CFB604","2042021kf0098"],"award-info":[{"award-number":["2020CFB604","2042021kf0098"]}]},{"name":"Young Teachers Funding Project of Wuhan University","award":["2020CFB604","2042021kf0098"],"award-info":[{"award-number":["2020CFB604","2042021kf0098"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Our previous study showed that interleukin\u201022 (IL\u201022) levels were increased in patients with aortic dissection (AD). This study evaluated the effects of IL\u201022 on AD\/abdominal aortic aneurysm (AAA) formation in angiotensin II (Ang II)\u2010infused ApoE\u2010\/\u2010 mice. <jats:italic>Methods.<\/jats:italic> ApoE\u2010\/\u2010 mice were treated with Ang II for 28 days, and IL\u201022 expression was examined. In addition, the effects of IL22 deficiency on AAA\/AD formation induced by Ang II infusion in ApoE\u2010\/\u2010 mice were investigated. ApoE\u2010\/\u2010IL\u201022\u2010\/\u2010 mice were transplanted with bone marrow cells isolated from ApoE\u2010\/\u2010 mice or ApoE\u2010\/\u2010IL\u201022\u2010\/\u2010 mice, and AAA\/AD formation was observed. <jats:italic>Results.<\/jats:italic> IL\u201022 expression was increased in both the aortas and serum of ApoE\u2010\/\u2010 mice after Ang II infusion and was mainly derived from aortic CD4+ T lymphocytes (CD4+ TCs). IL\u201022 deficiency significantly reduced the AAA\/AD formation as well as the maximal aortic diameter in Ang II\u2010infused ApoE\u2010\/\u2010 mice. Decreased elastin fragmentation and reduced fibrosis were observed in the aortas of ApoE\u2010\/\u2010IL\u201022\u2010\/\u2010 mice compared with ApoE\u2010\/\u2010 mice. The deletion of IL\u201022 also decreased aortic M1 macrophage differentiation, alleviated M1 macrophage\u2010induced oxidative stress, and reduced aortic smooth muscle cell loss. Furthermore, M1 macrophage\u2010induced oxidative stress was worsened and AAA\/AD formation was promoted in ApoE\u2010\/\u2010IL\u201022\u2010\/\u2010 mice that received transplanted bone marrow cells from ApoE\u2010\/\u2010 mice compared with those that were transplanted with bone marrow cells isolated from ApoE\u2010\/\u2010IL\u201022\u2010\/\u2010 mice. <jats:italic>Conclusions.<\/jats:italic> IL\u201022 deficiency inhibits AAA\/AD formation by inhibiting M1 macrophage\u2010induced oxidative stress. IL\u201022 potentially represents a promising new target for preventing the progression of AAA\/AD.<\/jats:p>","DOI":"10.1155\/2022\/7555492","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T01:05:07Z","timestamp":1647651907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interleukin\u201022 Deficiency Reduces Angiotensin II\u2010Induced Aortic Dissection and Abdominal Aortic Aneurysm in ApoE\u2010\/\u2010 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