{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:10:32Z","timestamp":1780085432810,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:p>Peptic ulcer is a universal condition that is a public health problem due to its prevalence, risk of complications and socioeconomic impact. This study aimed to determine the antiulcer effect of the hydroalcoholic extract from Senna multiglandulosa leaves against ethanol-induced gastric ulcer in rats. Thirty-six male albino Holtzman rats were assigned to six groups. Group I received physiological saline (PS) at doses of 10\u2009mL\/kg; group II: ethanol (PS\u2009+\u2009ethanol 5\u2009mL\/kg); group III; omeprazole 100\u2009mg\/kg\/day (gold standard); groups IV, V and VI received doses of 100, 250 and 500\u2009mg\/kg\/day of S. multiglandulosa extract, respectively. The stomach was removed to determine the ulcerative lesions and two sections of the glandular zone to carry out the analysis of the gastric mucus and sulfhydryl groups content. As result, S. multiglandulosa at doses of 250 and 500\u2009mg\/kg produced a significant decrease of the injured area, with values of 46.28\u2009\u00b1\u20097.95\u2009mm2 and 6.91\u2009\u00b1\u20092.48\u2009mm2, respectively (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.001<\/a:mn><\/a:math><\/jats:inline-formula>). The protective effect was showed at dose of 500\u2009mg\/kg (92.27%) and a significant increase in the production of mucus with a value of 83.13\u2009\u00b1\u200913.09\u2009mg\/mL\/g of tissue (61.14%). The production of nonprotein sulfhydryl groups (NP-SG) also increased significantly at the three evaluated doses, being 250.34\u2009\u00b1\u200921.16\u2009\u03bcg\/g tissue at dose of 500\u2009mg\/kg (119.94%). It is concluded that S. multiglandulosa extract protected against ethanol-induced gastric ulcer due to increased gastric mucus secretion and its antioxidant activity due to the generation of nonprotein sulfhydryl groups.<\/jats:p>","DOI":"10.1155\/2022\/7570294","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T22:35:06Z","timestamp":1660343706000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Antiulcer Effect of Senna multiglandulosa via Increased Secretion of Mucus and Nonprotein Sulfhydryl Groups in an Experimental Murine Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-7766","authenticated-orcid":true,"given":"Miriam","family":"Palomino-Pacheco","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-5976","authenticated-orcid":true,"given":"Juan Pedro","family":"Rojas-Armas","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-1908","authenticated-orcid":true,"given":"Jorge Luis","family":"Arroyo-Acevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-7512","authenticated-orcid":true,"given":"Jos\u00e9 Manuel","family":"Ortiz-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6465-8747","authenticated-orcid":true,"given":"Hugo Jes\u00fas","family":"Justil-Guerrero","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-1412","authenticated-orcid":true,"given":"Edwin C\u00e9sar","family":"Cieza-Macedo","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Av. Miguel Grau 755, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-1330","authenticated-orcid":true,"given":"Norma","family":"Ramos-Cevallos","sequence":"additional","affiliation":[{"name":"Research Institute for Pharmaceutical Sciences and Natural Resources, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Jr. Puno 1002, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9387-5492","authenticated-orcid":true,"given":"Mohammed Merae","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran 61441, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-8626","authenticated-orcid":true,"given":"Shafi","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Shine-Dalgarno Centre for RNA Innovation, The Australian National University, Canberra, ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-0961","authenticated-orcid":true,"given":"Oscar","family":"Herrera-Calderon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Jr. Puno 1002, Lima 15001, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/jcm8020179","article-title":"Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options","volume":"8","author":"L. 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