{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:18:23Z","timestamp":1767169103502,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Construction Fund of Medical Key Disciplines of Hangzhou","award":["OO20200485"],"award-info":[{"award-number":["OO20200485"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,5,12]]},"abstract":"<jats:p>\n                    Background. The efficacy and safety of cisapride in functional constipation (FC) remain unclear. This meta-analysis aimed at investigating the efficacy and safety of cisapride and Maren pill in the treatment of FC. Material and Methods. PubMed, Web of Science, Embase, Cochrane Library, WANFANG DATA, VIP, and CNKI databases were searched from inception to December 2021 for eligible comparative studies investigating the effects and safety of cisapride and Maren pill for FC. The primary outcome was the therapeutic effectiveness rate. The secondary outcomes were recurrence rate and incidence of adverse events. Results. A total of 526 studies were screened out by searching the electronic databases and by manually searching the relevant reference lists. According to the four-step process (identification, screening, eligibility, and inclusion) to select studies for meta-analysis, 521 articles were excluded. Finally, 5 studies with a total of 414 patients with FC were included in the quantitative analysis after sequential exclusion. The cisapride group had a significantly higher effectiveness rate than the control one (90.78% vs 64.97%,\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The incidence of adverse events in the cisapride group was lower than that in the Maren pill group (10.08% vs 13.95%,\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). Similarly, the recurrence rate of the cisapride group was lower than that of the Maren pill group (32.31% vs 53.16%,\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. For FC patients, cisapride is more effective than Maren pill; the recurrence rate and adverse event rate are lower than the latter, which makes it a better choice. The combination of cisapride and Maren pill is a direction of future research studies, which may increase the efficiency and reduce the dosage of cisapride.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7619998","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T19:50:09Z","timestamp":1652385009000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Cisapride versus Maren Pill for Functional Constipation: A Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yanming","family":"Sun","sequence":"first","affiliation":[{"name":"Critical Care Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-992X","authenticated-orcid":true,"given":"Rui","family":"Ye","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Affiliated Hangzhou First People\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"554","article-title":"New insights into irritable bowel syndrome: from pathophysiology to treatment","volume":"32","author":"A. Hadjivasilis","year":"2019","journal-title":"Annals of Gastroenterology"},{"key":"2","first-page":"18","article-title":"Consensus on diagnosis and treatment of functional constipation with integrated traditional Chinese and western medicine (2017)","volume":"26","author":"Li Junxiang","year":"2018","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine on Digestion"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13762"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0222-y"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1688784"},{"key":"6","first-page":"200","article-title":"The types of dysmotility in chronic constipation and its guiding significance for treatment","author":"G. Xiaofeng","year":"2003","journal-title":"Chinese Journal of Gastroenterology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.90.313"},{"key":"8","first-page":"78","article-title":"Clinical effect and safety analysis of cisapride in the treatment of functional constipation","volume":"17","author":"B. Zhang","year":"2019","journal-title":"JOURNAL OF CHINA PRESCRIPTION DRUG"},{"key":"9","first-page":"99","article-title":"Clinical effect and safety analysis of cisapride in the treatment of functional constipation","volume":"24","author":"X. Yang","year":"2017","journal-title":"CHINA MODERN MEDICINE"},{"key":"10","article-title":"Clinical observation of cisapride in the treatment of functional constipation","volume":"26","author":"X. Liu","year":"2017","journal-title":"JOURNAL OF FRONTIERS OF MEDICINE"},{"key":"11","first-page":"30","article-title":"Clinical observation of cisapride in the treatment of functional constipation","volume":"4","author":"Z. He","year":"2010","journal-title":"CHINESE JOURNAL OF MODERN DURG APPLICATION"},{"key":"12","article-title":"Therapeutic effect of cisapride on functional constipation","volume":"6","author":"J. Shi","year":"2003","journal-title":"STRAIT PHARMACEUTICAL JOURNAL"},{"key":"13","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD007780.pub2","volume-title":"Cisapride for Intestinal Constipation","author":"O. M. Aboumarzouk","year":"2011"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100111"},{"key":"15","first-page":"345","article-title":"Use of cisapride with magnesium oxide in chronic pediatric constipation","volume":"42","author":"Y. H. Ni","year":"2001","journal-title":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199512060-00004"},{"key":"17","first-page":"2502","article-title":"Clinical observation of maren soft capsule in treating constipation caused by antipsychotic drugs","volume":"47","author":"F. Ye","year":"2016","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"18","first-page":"466","article-title":"Clinical observation of maren soft capsule in treating constipation after stroke","volume":"47","author":"Z. Chen","year":"2016","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"19","first-page":"2127","article-title":"Effect of Maren Soft Capsule on constipation in elderly patients with acute exacerbation of COPD complicated with sepsis","volume":"39","author":"P. Zhang","year":"2019","journal-title":"Chinese Journal of Gerontology"},{"key":"20","volume-title":"Maren Soft Capsule for the Treatment of Opioid-Related Constipation in a Randomized, Double-Blind, Controlled Clinical Study","author":"L. Wu","year":"2019"},{"key":"21","first-page":"1126","article-title":"Clinical observation of maren soft capsule in preventing constipation after anorectal surgery","volume":"45","author":"J. 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