{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:16:01Z","timestamp":1790878561487,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["R.G.P.2\/146\/43"],"award-info":[{"award-number":["R.G.P.2\/146\/43"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Avicennia alba<\/jats:italic> is a mangrove plant that is extensively used to treat severe health issues. This focus of this study was to investigate the antidiabetic, anti\u2010inflammatory, analgesic, and antidiarrheal activities of methanolic extract of <jats:italic>A. alba<\/jats:italic> leaves in Swiss albino mouse model. The antidiabetic, anti\u2010inflammatory, analgesic, and antidiarrheal activities of the leaf extract were performed using alloxan\u2010monohydrate, carrageenan\u2010induced paw edema, acetic acid\u2010induced writhing test and the hot plate method, and castor oil\u2010induced method, respectively. The extract was used at doses ranging from 200 to 500\u2009mg\/kg to conduct the investigation. Leaf extract at 400 and 500\u2009mg\/kg showed potent antidiabetic activity in alloxan\u2010induced diabetic mice. Advanced research is needed to control blood glucose levels and carrageenan paw edema\u2010based anti\u2010inflammatory effects. Both tests showed statistically significant result in a dose\u2010dependent manner. The maximum dose (500\u2009mg\/kg) demonstrated potent analgesic activity in both writhing test and hot plate method. The plant extract also showed significant antidiarrheal activity at 400 and 500\u2009mg\/kg in experimental mice. However, more research is needed to explore the possible mechanisms and isolate the compounds associated with these bioactivities from the leaf extract of <jats:italic>A. alba<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/2022\/7624189","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T18:07:32Z","timestamp":1651860452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacological Potential of <i>Avicennia alba<\/i> Leaf Extract: An Experimental Analysis Focusing on Antidiabetic, Anti\u2010inflammatory, Analgesic, and Antidiarrheal Activity"],"prefix":"10.1155","volume":"2022","author":[{"given":"Saikat","family":"Mitra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-8264","authenticated-orcid":false,"given":"Fahadul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7852-4080","authenticated-orcid":false,"given":"Rajib","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Urmee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aklima","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-4769","authenticated-orcid":false,"given":"Abubakr M.","family":"Idris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayeen Uddin","family":"Khandaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad A.","family":"Almikhlafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-3573","authenticated-orcid":false,"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3188-2272","authenticated-orcid":false,"given":"Talha Bin","family":"Emran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"874","article-title":"Analgesic and antipyretic activities of the methanolic extract of aerial parts of Avicennia alba Blume","volume":"6","author":"Kar D. 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