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The current study was planned to find the resistance modulation and toxicity potential of sodium alginate stabilized MgO nanoparticles and antibiotics against <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) isolated from the gut of Houbara bustard bird (<jats:italic>n<\/jats:italic> = 105 fecal samples). The preparations consisted of gel stabilized ampicillin (G+A), gel stabilized MgO and ampicillin (G+M+A), gel stabilized MgO and cefoxitin (G+M+C), gel stabilized tylosin (G+T), gel stabilized MgO and tylosin (G+M+T), and gel stabilized MgO (M+G). The fecal samples showed 53% (56\/105) prevalence of <jats:italic>E. coli<\/jats:italic> which was found to be significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) associated with most of the assumed factors and resistant to multiple drugs. G+M+T showed the lowest (4.883 \u00b1 0.00 <jats:italic>\u03bc<\/jats:italic>g\/mL) minimum inhibitory concentration (MIC) followed G+M+C, G+M+A, G+A, M+G, and G+T. Significant reduction (<jats:italic>p<\/jats:italic> &lt; 0.05) in MIC with respect to incubation interval found at the 16<jats:sup>th<\/jats:sup> hr for G+M+A, G+A, and G+M+C that further remained nonsignificant (<jats:italic>p<\/jats:italic> &gt; 0.05) onwards until the 24<jats:sup>th<\/jats:sup> hr of incubation. In the case of G+T and M+G, significant reduction in MIC was found at the 20<jats:sup>th<\/jats:sup> hr and 24<jats:sup>th<\/jats:sup> hr of incubation. Ecotoxicology and histopathology trials on snails showed mild changes in MICs of the preparations. The study thus concluded increasing drug resistance in <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> of houbara bird while sodium alginate stabilized MgO nanoparticles and antibiotics were effective alternative antibacterial composites with mild toxicity.<\/jats:p>","DOI":"10.1155\/2022\/7627759","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T23:50:09Z","timestamp":1663026609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Sodium Alginate Stabilized Nanoparticles and Antibiotics against Drug Resistant <i>Escherichia coli<\/i> Isolated from Gut of Houbara Bustard Bird"],"prefix":"10.1155","volume":"2022","author":[{"given":"Afshan","family":"Muneer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-3948","authenticated-orcid":false,"given":"Amjad Islam","family":"Aqib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanza Rauf","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Qaswar Ali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Zaheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauseef ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheen","family":"Murtaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Waseem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10020190"},{"key":"e_1_2_9_2_2","first-page":"98","article-title":"Isolation, identification and characterization of salmonella spp. from chicken purchased at Wad Madani City, Gezira state, Sudan","volume":"8","author":"Sulieman A. 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