{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:22:10Z","timestamp":1768281730847,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,23]]},"abstract":"<jats:p>Background. Artesunate (AS) is a derivative of artemisinin that can exert anti-inflammatory effects. This study aims to explore the effect of AS on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS). Methods. The newborn mice were used for experimental ARDS model establishment by intraperitoneal injection of LPS (10\u2009mg\/kg) into mice with or without AS (20\u2009mg\/kg) pretreatment. After that, the pathological morphology of mouse lung tissue was observed by H&amp;E staining. The content of inflammatory factors in serum was measured by ELISA and mRNA expression and lung tissue was determined by qRT-PCR. The expression of NLRP3 inflammasome and related proteins in lung tissue was confirmed by immunohistochemistry and Western blot. Results. AS treatment effectively alleviated the LPS-induced lung injury and pulmonary edema, and reduced the expression of IL-1\u03b2, IL-18, IL-6, IL-8, MCP-1, and TNF-\u03b1 in serum and lung tissues of experimental ARDS mice. In addition, AS treatment reduced the expression of NLRP3, ASC, and caspase-1 in lung tissues of experimental ARDS mice. Conclusion. AS alleviated LPS-induced lung injury in ARDS mice by inhibiting the activation of NLRP3 inflammasome.<\/jats:p>","DOI":"10.1155\/2022\/7655033","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T23:50:14Z","timestamp":1661298614000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["The Protective Effect of Artesunate on LPS-Induced Acute Respiratory Distress Syndrome through Inhibiting NLRP3 Inflammasome Signaling"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-9655","authenticated-orcid":true,"given":"Yifei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Children\u2019s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Weng","sequence":"additional","affiliation":[{"name":"The Yuyao Health Further 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