{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:55:41Z","timestamp":1767167741943,"version":"build-2238731810"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":234,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dalian University","award":["2020QL016"],"award-info":[{"award-number":["2020QL016"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Currently, there are few studies on biomarkers for predicting coronary heart disease (CHD) with anxiety disorders.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To explore risk factors and investigate the predictive value of common clinical peripheral blood indicators, such as high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and homocysteine (Hcy) for CHD patients with anxiety disorders.\n                    <jats:italic>Methods<\/jats:italic>\n                    . One hundred fifty\u2010three hospitalized patients with chest pain as the main symptom and a Hamilton\u2009Anxiety\u2009Scale\u2009score &gt; 14 were recruited from October 2020 to September 2021 in the hospital. Then, they were divided into an anxiety disorder with CHD group (observation group,\n                    <jats:italic>n<\/jats:italic>\n                    = 64) and a simple anxiety disorder group (control group,\n                    <jats:italic>n<\/jats:italic>\n                    = 89), according to coronary angiography (CAG) findings. Patients\u2019 demographic and clinical messages were collected and compared. Diabetes mellitus and hypertension, body mass index (BMI), and peripheral blood interleukin\u20106 (IL\u20106), high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), homocysteine (Hcy), fibrinogen, D\u2010dimer, cortisol, and norepinephrine expression levels were compared. Binary logistic regression analysis screened independent risk factors of CHD patients with anxiety disorders. The effectiveness of independent risk factors in predicting CHD with anxiety disorders was analyzed using receiver operating characteristic (ROC) curves.\n                    <jats:italic>Results<\/jats:italic>\n                    . IL\u20106, hs\u2010CRP, and Hcy levels of anxiety disorder in the CHD group were significantly higher than those in the simple anxiety disorder group. Binary multiple logistic regression analysis indicated that IL\u20106, hs\u2010CRP, and Hcy were independent risk factors for CHD in patients with anxiety disorders. hs\u2010CRP and Hcy levels were positively correlated with the Gensini score. ROC curve analysis indicated that the detection of hs\u2010CRP or Hcy alone or the combined detection of the 2 had clinical predictive value for CHD in patients with anxiety disorders, and the area under the curve (AUC) of the combined detection of the 2 was significantly larger than that of any single factor alone (vs. hs\u2010CRP,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.045; vs. Hcy,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.045).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . IL\u20106, hs\u2010CRP, and Hcy are related to CHD with anxiety disorders. Serum levels of the combined detection of hs\u2010CRP and Hcy have a high clinical predictive value for CHD in patients with anxiety disorders.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7657347","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T19:05:17Z","timestamp":1661281517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["[Retracted] Predictive Significance of High\u2010Sensitivity C\u2010Reactive Protein Combined with Homocysteine for Coronary Heart Disease in Patients with Anxiety Disorders"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-541X","authenticated-orcid":false,"given":"Changhe","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuirong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2015.0459a"},{"key":"e_1_2_10_2_2","first-page":"224","article-title":"Effect of pravastatin combined with metoprolol on cardiac function, glycolipid metabolism and other related indicators in patients with diabetes mellitus complicated with coronary heart disease","volume":"11","author":"Han S. S.","year":"2019","journal-title":"Journal of Molecular Diagnostics and Therapy"},{"key":"e_1_2_10_3_2","first-page":"116","article-title":"Based on the intestinal micro-ecosystem, the spleen theory is discussed in the treatment of coronary heart disease","volume":"21","author":"He Y. Z.","year":"2019","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"key":"e_1_2_10_4_2","first-page":"85","article-title":"Research advances related to homocysteine and Alzheimer's disease","volume":"30","author":"Huang G. C.","year":"2019","journal-title":"Public Health and Preventive Medicine"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0559-1"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.034"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.711"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-016-0739-5"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005407"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.11.029"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv047"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0800-3"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S358763"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox242"},{"key":"e_1_2_10_15_2","article-title":"Association of SDF1 and MMP12 with atherosclerosis and inflammation","volume":"11","author":"Marcos-Jubilar M.","year":"2021","journal-title":"Clinical and Experimental Study"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27945"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3054-5"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.12.008"},{"key":"e_1_2_10_20_2","article-title":"Targeting inflammatory pathways in cardiovascular disease: the inflammasome, interleukin-1, interleukin-6 and beyond","volume":"10","author":"Libby P.","year":"2021","journal-title":"Cell"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005077"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.18433\/jpps29872"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.02.035"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2017.02.001"},{"key":"e_1_2_10_25_2","first-page":"966","article-title":"C-reactive protein as a prognostic marker in patients with hepatocellular carcinoma","volume":"62","author":"Kinoshita A.","year":"2015","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.2741\/s508"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(01)00042-6"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.12.007"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00359-7"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6394(2000)12:1 <69::AID-DA9>3.0.CO;2-K"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2004.11.003"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.146"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.07.027"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2019.01.003"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.05.036"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.03.011"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.02.035"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.109975"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.08.082"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2018.1433325"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027925"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.03.123"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.6.861"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.108"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-6"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.11.145"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8817"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1001"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.618"}],"updated-by":[{"DOI":"10.1155\/2023\/9787406","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"record-id":"47855"},{"DOI":"10.1155\/2023\/9787406","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/7657347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/7657347.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7657347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T10:35:20Z","timestamp":1735641320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7657347"}},"subtitle":[],"editor":[{"given":"Yuvaraja","family":"Teekaraman","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7657347"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7657347","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7657347"}}