{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:25:49Z","timestamp":1767165949540,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,4,21]]},"abstract":"<jats:p>\n                    Objective. To analyze the effect of different doses of propofol on pulmonary function and inflammatory response in patients with lung ischemia reperfusion injury (LIRI) induced by one-lung ventilation (OLV) based on big data analysis. Methods. A retrospective study was performed on 105 patients who underwent lobectomy in our hospital (January 2018 to January 2022). According to the doses of propofol, they were split into low-dose group (LDG), middle-dose group (MDG), and high-dose group (HDG), which received the continuous micropump infusion of propofol at the doses of 2\u2009mg\/(kg\u00b7h), 5\u2009mg\/(kg\u00b7h), and 10\u2009mg\/(kg\u00b7h) after induction, respectively, with 35 cases in each group. The indexes, such as the pulmonary function and inflammatory factors of patients, at different times were compared. The logistic regression analysis was performed according to the occurrence of LIRI. Results. With no notable difference at T0 among the three groups (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ), the Cdyn levels significantly decreased at T1 (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ) and gradually increased at T2. The Cdyn levels at T1 and T2 were remarkably higher in HDG and MDG than in LDG (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). With no notable differences at T0 and T1 among the three groups (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&gt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ), the PA-aO2 levels and RI values at T2 in MDG and HDG were lower compared with LDG (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). The RI values at T1 and T2 in HDG were higher compared with MDG, with no obvious difference (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&gt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ). The OI levels at T1 and T2 in HDG were lower compared with the other two groups (\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.05<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ), and the OI levels at T1, T2, and T3 in LDG were higher compared with MDG, with no obvious difference (\n                    <jats:inline-formula>\n                      <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>&gt;<\/o:mo>\n                        <o:mn>0.05<\/o:mn>\n                      <\/o:math>\n                    <\/jats:inline-formula>\n                    ). The TNF-\u03b1 and ICAM-1 levels at T1 and T2 in MDG and HDG were lower compared with LDG, with no obvious difference between MDG and HDG (\n                    <jats:inline-formula>\n                      <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>&gt;<\/q:mo>\n                        <q:mn>0.05<\/q:mn>\n                      <\/q:math>\n                    <\/jats:inline-formula>\n                    ). Compared with LDG, the MDG and HDG at T1 and T2 had lower MDA levels (\n                    <jats:inline-formula>\n                      <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>&lt;<\/s:mo>\n                        <s:mn>0.05<\/s:mn>\n                      <\/s:math>\n                    <\/jats:inline-formula>\n                    ) and higher SOD levels (\n                    <jats:inline-formula>\n                      <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>P<\/u:mi>\n                        <u:mo>&lt;<\/u:mo>\n                        <u:mn>0.05<\/u:mn>\n                      <\/u:math>\n                    <\/jats:inline-formula>\n                    ). Logistic regression analysis showed that Cdyn, PA-aO2, and OLV time were independent risk factors for LIRI in patients undergoing lobectomy. Conclusion. Propofol has a good protective effect on lung function in patients with OLV-induced LIRI. Appropriately increasing the dose of propofol can effectively improve the local cerebral hypoxia and lung compliance of patients and reduce the inflammatory response and oxidative stress response, with 5\u2009mg\/(kg\u00b7h) as the clinical reference. Preoperative assessment and preparation should be made for patients, close attention should be paid to risk factors, such as Cdyn and PA-aO2, and OLV time should be controlled.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7677266","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T16:05:48Z","timestamp":1650557148000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Different Doses of Propofol on Pulmonary Function and Inflammatory Response in Patients with Lung Ischemia Reperfusion Injury Induced by One-Lung Ventilation Based on Big Data Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yi","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-6530","authenticated-orcid":true,"given":"Tianyu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boxiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Short-interval exposure to ambient fine particulate matter (PM2.5) exacerbates the susceptibility of pulmonary damage in setting of lung ischemia-reperfusion injury in rodent: pharmacomodulation of melatonin","volume":"113","author":"L. Fan-Yen","year":"2019","journal-title":"Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie"},{"issue":"1 Pt.B","key":"2","first-page":"1228","article-title":"Amelioration of lung ischemia-reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia-reperfusion injury lung transplantation model","volume":"17","author":"J. Wang","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12493"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/FJC.0000000000000978","article-title":"Overlapping effects of miR-21 inhibition and drugs for idiopathic pulmonary fibrosis: rationale for repurposing nintedanib as a novel treatment for ischemia\/reperfusion injury","volume":"77","author":"E. Alberto","year":"2021","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104292"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.transproceed.2019.01.059","article-title":"Erythropoietin ameliorates lung injury by accelerating pulmonary endothelium cell proliferation via janus kinase-signal transducer and activator of transcription 3 pathway after kidney ischemia and reperfusion injury","volume":"51","author":"L. Wang","year":"2019","journal-title":"Transplantation Proceedings"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519892432"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-865020190080000005"},{"issue":"2","key":"9","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X1501000209","article-title":"Effect of puerarin on expression of fas\\\/FasL mRNA in pulmonary injury induced by ischemia-reperfusion in rabbits","volume":"10","author":"M. Zheng","year":"2019","journal-title":"Natural Product Communications"},{"issue":"4","key":"10","article-title":"Post-treatment curcumin reduced ischemia-reperfusion-induced pulmonary injury via the Notch2\/Hes-1 pathway","volume":"48","author":"Z. Haibo","year":"2020","journal-title":"Journal of International Medical Research"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.04.047"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00221.2019"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.098"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10369"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1166\/jmihi.2020.3249"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0224oc"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2017.1296512"},{"issue":"4 Pt.B","key":"18","first-page":"3225","article-title":"Electroacupuncture pre-conditioning protects from lung injury induced by limb ischemia\/reperfusion through TLR4 and NF-kappa B in rats","volume":"22","author":"Y. Lou","year":"2020","journal-title":"Molecular Medicine Reports"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.048"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00367.2018"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-56847-6_16"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.08.098"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00004.2018"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00221.2019"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718761657"}],"updated-by":[{"DOI":"10.1155\/2023\/9859680","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"record-id":"54614"},{"DOI":"10.1155\/2023\/9859680","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000}}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7677266.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7677266.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2022\/7677266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T16:05:56Z","timestamp":1650557156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2022\/7677266\/"}},"subtitle":[],"editor":[{"given":"Kalidoss","family":"Rajakani","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":25,"alternative-id":["7677266","7677266"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7677266","relation":{},"ISSN":["2040-2309","2040-2295"],"issn-type":[{"value":"2040-2309","type":"electronic"},{"value":"2040-2295","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,21]]}}}