{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:14:03Z","timestamp":1792106043728,"version":"4.4.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19H040001"],"award-info":[{"award-number":["LY19H040001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    During testicular ischemia\u2010reperfusion, overproduction of reactive oxygen species is associated with testicular injury. We injected hydrogen peroxide (a representative of reactive oxygen species) into normal testis via the testicular artery. The experiment demonstrates that reactive oxygen species can cause spermatogenic injury. Salvianolic acid B, the most abundant bioactive component in\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    Bunge, has been reported to possess a potent antioxidant activity. This study was conducted to evaluate the effect of salvianolic acid B on testicular ischemia\u2010reperfusion injury in a rat testicular torsion\u2010detorsion model. Rats were randomly separated into three groups, including 20 rats in each group: control group with sham operation, testicular ischemia\u2010reperfusion group, and testicular ischemia\u2010reperfusion + salvianolic acid B\u2010treated group. In the testicular ischemia\u2010reperfusion group, left testicular torsion of 720\u00b0 for 2 hours was induced, and then testicular detorsion was carried out. Rats in the salvianolic acid B\u2010treated group additionally had salvianolic acid B administered intravenously at detorsion. At 4 hours after detorsion, testes of 10 rats from each group were collected to analyze the protein expression of xanthine oxidase which catalyzes generation of reactive oxygen species and malondialdehyde concentration (an indirect indicator of reactive oxygen species). At 3 months after detorsion, testes of the remaining 10 rats from each group were collected to analyze spermatogenesis. Compared with the control group, xanthine oxidase protein expression and malondialdehyde concentration in ipsilateral testes of testicular ischemia\u2010reperfusion group increased significantly, while spermatogenesis decreased significantly. In the salvianolic acid B\u2010treated group, xanthine oxidase protein expression and malondialdehyde concentration in ipsilateral testes decreased significantly, while spermatogenesis increased significantly, compared with the testicular ischemia\u2010reperfusion group. These results suggest that salvianolic acid B can attenuate testicular torsion\/detorsion\u2010induced ischemia\/reperfusion injury by downregulating the xanthine oxidase protein expression to inhibit reactive oxygen species formation.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7680182","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T19:50:05Z","timestamp":1642103405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Attenuation Effect of Salvianolic Acid B on Testicular Ischemia\u2010Reperfusion Injury in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-7110","authenticated-orcid":false,"given":"Si-Ming","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-07255-7.00077-5"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800751015"},{"key":"e_1_2_9_3_2","first-page":"1739","article-title":"Testicular torsion","volume":"74","author":"Ringdahl E.","year":"2006","journal-title":"American Family Physician"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1566096"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92056-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.13477"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.03.060"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2020.09.019"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.13922"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-017-9826-5"},{"key":"e_1_2_9_11_2","first-page":"170","article-title":"The oxidative stress response","volume":"3","author":"Camhi S. 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