{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:14:33Z","timestamp":1767168873264,"version":"build-2238731810"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,14]]},"abstract":"\n Objective. To investigate the effect of cryotherapy using ice pops for physical analgesia and preventive analgesia using flurbiprofen axetil for pain management in children undergoing tonsillectomy. Methods. A total of 120 children scheduled for tonsillectomy were recruited after assessment for eligibility and assigned to a control group (group C), flurbiprofen axetil group (group F), cryotherapy group (group I), and cryotherapy plus flurbiprofen axetil group (Group FI) via the random number table method. Groups F and FI were given 1\u2009mg\/kg of flurbiprofen axetil through intravenous injection 30\u2009min before surgery, while group C received an equal amount of saline at the same time point. Groups I and FI received sweet ice pops for pain relief after recovery from anesthesia. The modified Children\u2019s Hospital of Eastern Ontario Pain Scale (mCHEOPS) scores and pediatric anesthesia emergence delirium (PAED) scores at 5 minutes (T1), 30 minutes (T2), 60 minutes (T3), 4 hours (T4), and 24 hours (T5) postoperatively, and the incidence of postoperative complications in the children were recorded by investigators who were masked to the grouping results. Results. From T1 to T4, significantly lower mCHEOPS scores and PAED scores were observed in group F, group I, and group FI versus those in group C (\n \n \n P<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>\n ). At T2, group FI showed significantly lower mCHEOPS scores and PAED scores versus groups F and I (\n \n \n P<\/c:mi>\n <<\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\n ). There were no significant differences in the mCHEOPS scores and PAED scores between the four groups at 24\u2009h postoperatively (\n \n \n P<\/e:mi>\n ><\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\n ). The differences in the documented postoperative complications between the four groups did not come up to the statistical standard (\n \n \n P<\/g:mi>\n ><\/g:mo>\n 0.05<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>\n ). Conclusion. Cryotherapy plus flurbiprofen axetil for pain management significantly mitigates post-tonsillectomy pain and delirium in children and facilitates recovery, with no significant adverse events.\n <\/jats:p>","DOI":"10.1155\/2022\/7687437","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T21:05:23Z","timestamp":1657832723000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Cryotherapy plus Flurbiprofen Axetil for Pain Management in Children Undergoing Tonsillectomy"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ping","family":"Gao","sequence":"first","affiliation":[{"name":"School of Nursing, Anhui Medical University, Department of Emergency Medical, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-1398","authenticated-orcid":true,"given":"Biaoxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.10.016"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208001-00004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s1040-8428(01)00129-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/0194599816661715"},{"issue":"2","key":"5","first-page":"121","article-title":"Comparative study of diclofenac sodium and paracetamol for treatment of pain after adenotonsillectomy in children","volume":"22","author":"M. 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