{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:08:57Z","timestamp":1780816137639,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Science and Technology Project Fund for Key Scientific Research Base","award":["2019B020230001"],"award-info":[{"award-number":["2019B020230001"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>We aim to identify the common genes, biological pathways, and treatment targets for primary Sj\u00f6gren\u2019s syndrome patients with varying degrees of fatigue features. We select datasets about transcriptomic analyses of primary Sj\u00f6gren\u2019s syndrome (pSS) patients with different degrees of fatigue features and normal controls in peripheral blood. We identify common differentially expressed genes (DEGs) to find shared pathways and treatment targets for pSS patients with fatigue and design a protein\u2010protein interaction (PPI) network by some practical bioinformatic tools. And hub genes are detected based on the PPI network. We perform biological pathway analysis of common genes by Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Lastly, potential treatment targets for pSS patients with fatigue are found by the Enrichr platform. We discovered that 27 DEGs are identified in pSS patients with fatigue features and the severe fatigued pSS\u2010specific gene is RTP4. DEGs are mainly localized in the mitochondria, endosomes, endoplasmic reticulum, and cytoplasm and are involved in the biological process by which interferon acts on cells and cells defend themselves against viruses. Molecular functions mainly involve the process of RNA synthesis. The DEGs of pSS are involved in the signaling pathways of viruses such as hepatitis C, influenza A, measles, and EBV. Acetohexamide PC3 UP, suloctidil HL60 UP, prenylamine HL60 UP, and chlorophyllin CTD 00000324 are the four most polygenic drug molecules. PSS patients with fatigue features have specific gene regulation, and chlorophyllin may alleviate fatigue symptoms in pSS patients.<\/jats:p>","DOI":"10.1155\/2022\/7697558","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T13:50:06Z","timestamp":1642254606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sj\u00f6gren\u2019s Syndrome Patients with Fatigue"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6718-8667","authenticated-orcid":false,"given":"Guangshu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-7672","authenticated-orcid":false,"given":"Li","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-2265","authenticated-orcid":false,"given":"Xingdong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-5563","authenticated-orcid":false,"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-9469","authenticated-orcid":false,"given":"Jianmin","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90001-5"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1996.418817000.x"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3487"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22720"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3035-6"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/14034940410028406"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000282"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew008"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916633236"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.10.003"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.1.207"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.9834"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29001"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.09.012"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3578-9_5"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki470"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti1016"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-019-1605-9"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz240"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199612000-00011"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22263"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel021"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3800"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(88)80004-6"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004411"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.07.012"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-004-0463-z"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1196"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22968"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006820"},{"key":"e_1_2_11_36_2","first-page":"129","volume-title":"Sjogren's Syndrome: Diagnosis and Therapeutics","author":"Segal B.","year":"2012"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem004"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20299"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.20146"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.04.007"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00278-X"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.6.1437"},{"key":"e_1_2_11_43_2","first-page":"735","article-title":"The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and cyclin D1 depletion","volume":"16","author":"Chiu L. C.","year":"2005","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi068"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2003.11.008"},{"key":"e_1_2_11_46_2","unstructured":"Coronavirus Resource Center Johns Hopkins University COVID-19 Dashboard November 2021 https:\/\/coronavirus.jhu.edu\/map.html."},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25829"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.04.086"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0402-2"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.620175"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2013.859853"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666160912180155"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf010869g"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400639"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3232080"},{"key":"e_1_2_11_56_2","volume-title":"Bioinformatic analysis identifies biomarkers and treatment targets in primary Sj\u00f6gren's syndrome patients with fatigue","author":"Chen G.","year":"2021"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/7697558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2022\/7697558.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/7697558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T19:25:18Z","timestamp":1735673118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/7697558"}},"subtitle":[],"editor":[{"given":"Paul","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/7697558"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7697558","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-829258\/v1","asserted-by":"object"}]},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7697558"}}