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The itchy, scaly, and erythematous lesions present on psoriatic skin negatively affect patients\u2019 quality of life. Pinocembrin is a flavonoid present in propolis, fruits, and vegetables. It exerts neuroprotective effects and was used for treating ischemic stroke in a human clinical trial. However, the effects of pinocembrin on psoriasis have never been examined. In this study, we evaluated the effects of pinocembrin on human HaCaT keratinocytes and BALB\/c mice with imiquimod- (IMQ-) induced psoriatic dermatitis. In interferon-\u03b3- (IFN-\u03b3-) activated HaCaT cells, pinocembrin reduced the expression of inflammatory cytokines, namely, tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-6 (IL-6), and keratinocyte proliferation markers, namely, keratin (K)16, K17, and Ki-67. The mechanism underlying these inhibitory effects involved the regulation of the heme oxygenase- (HO-) 1\/signal transducer and activator of transcription (STAT) 3 pathway. In the IMQ-induced psoriatic dermatitis mouse model, the topical application of pinocembrin significantly ameliorated the Skin Psoriasis Area and Severity Index score, epidermal thickness, inflammation, hyperplasia, hyperkeratosis, and cluster of differentiation (CD) 4+ T-cell infiltration. Expression of the inflammatory cytokines and keratinocyte proliferation markers in dorsal skin was significantly decreased in the pinocembrin-treated group. Meanwhile, in lesional skin, the expression of HO-1 was upregulated, but that of phospho-STAT3 (pSTAT3) was downregulated. Collectively, our results indicated the therapeutic potential of pinocembrin. Additional studies are warranted to evaluate its clinical benefits in patients with psoriasis.<\/jats:p>","DOI":"10.1155\/2022\/7729836","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T20:51:10Z","timestamp":1643143870000},"page":"1-21","source":"Crossref","is-referenced-by-count":6,"title":["Pinocembrin Reduces Keratinocyte Activation and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in BALB\/c Mice through the Heme Oxygenase-1\/Signal Transducer and Activator of Transcription 3 Pathway"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-9394","authenticated-orcid":true,"given":"Kuo-Kuei","family":"Huang","sequence":"first","affiliation":[{"name":"Natural Medicine and Healthcare Technology Division, Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 30011, 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