{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:26:04Z","timestamp":1767165964599,"version":"build-2238731810"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017291","name":"Zhongshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2016B1004"],"award-info":[{"award-number":["2016B1004"]}],"id":[{"id":"10.13039\/501100017291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,9,7]]},"abstract":"<jats:p>Objective. Shen-Ling-Bai-Zhu-San (SLBZS) is used for treating gastrointestinal disorders. However, the role of SLBZS in treating pneumonia in children is still unclear. Methods. In this study, children (\u22652 and &lt;9 years) with pneumonia were treated with 0.1\u2009g cefixime (cefixime group) or 0.1\u2009g cefixime\u2009+\u20099\u2009g SLBZS (SLBZS\u2009+\u2009cefixime). The drugs were administered twice daily for 10 days. The therapeutic effects of the two groups were compared. The white blood cell (WBC), neutrophil, and lymphocyte counts; neutrophil-lymphocyte ratio (NLR); serum inflammatory factor levels; and gut microflora were assessed. Results. The clinical efficacy of SLBZS\u2009+\u2009cefixime treatment of pneumonia in children was higher than that of cefixime alone (93.3% vs. 86.7%). Both cefixime and SLBZS\u2009+\u2009cefixime treatments decreased the area of pulmonary inflammatory lesions, reduced white blood cell and neutrophil counts, neutrophil-lymphocyte ratio, inflammation, and increased lymphocyte count in children with pneumonia compared with those before treatment. Moreover, SLBZS enhanced the anti-inflammation and immunity-enhancing effects of cefixime in children with pneumonia. SLBZS\u2009+\u2009cefixime treatment decreased Enterobacter, Enterococcus, Bacteroides, and Fusobacterium counts and increased Bifidobacterium and Lactobacillus counts. Compared with the cefixime treatment group, the count of the six bacterial strains in the SLBZS\u2009+\u2009cefixime treatment group was closer to the normal level. Conclusion. SLBZS enhanced the antipneumonia effect of cefixime in children with pneumonia by ameliorating gut microflora, inflammation, and immune response.<\/jats:p>","DOI":"10.1155\/2022\/7752426","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T19:20:09Z","timestamp":1662578409000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Shen-Ling-Bai-Zhu-San Enhances the Antipneumonia Effect of Cefixime in Children by Ameliorating Gut Microflora, Inflammation, and Immune Response"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-6237","authenticated-orcid":true,"given":"Jinli","family":"Feng","sequence":"first","affiliation":[{"name":"Emergency Department, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency Department, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency Department, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Emergency Department, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Degen","family":"He","sequence":"additional","affiliation":[{"name":"Pediatrics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Pan","sequence":"additional","affiliation":[{"name":"Prevention and Health Section, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Pediatrics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatrics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozheng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Pediatrics, Zhongshan Hospital, Guangzhou University of Chinese Medicine, Zhongshan, Guangdong 528401, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-016-0661-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1996151"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000002016"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1340937"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000012337"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/671013"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221199"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0649-9"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2019.10.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.34"},{"key":"11","first-page":"113","article-title":"Changes in gut microbiota and serum d-lactate level and correlation analysis in children with recurrent pneumonia","volume":"18","author":"S. 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