{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:30:25Z","timestamp":1782311425866,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960106"],"award-info":[{"award-number":["81960106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,31]]},"abstract":"<jats:p>Background. Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that commonly affects the health of many individuals. Esculentoside A (EsA), a saponin extracted from the roots of Phytolacca esculenta, has antioxidative and anti-inflammatory effects against various diseases. Nonetheless, its role in UC is undetermined. Hence, in this study, we examined the therapeutic effects of EsA in UC. Methods. Primary intestinal neuronal cells (in vitro) were treated with lipopolysaccharide (LPS) to induce inflammatory injury. An in vivo UC rat model was created by the administration of dextran sulfate sodium (DSS) to rats, which were subsequently treated with different doses of EsA. The effects of EsA on intestinal motility, histological score, inflammatory response, hydrogen sulfide (H2S)\/cystathionine \u03b3-lyase (CSE) system, NO\/neuronal nitric oxide synthase (nNOS) system, and LPS-induced primary intestinal neuronal cell viability loss, proliferation inhibition, and apoptosis were detected. Results. In vitro, EsA treatment increased the number of DSS-inhibited bowel movements and body weight, improved the histological score of colitis, and inhibited the inflammatory response by reducing IL-6 and TNF-\u03b1 levels in rats. More importantly, EsA reduced the NO and H2S levels in serum and CSE, CBS, and nNOS expressions in the colon tissue. In vivo, EsA treatment eased the viability loss, proliferation inhibition, and apoptosis of LPS-stimulated primary intestinal neuronal cells, as well as inhibited the expressions of IL-6, TNF-\u03b1, CSE, CBS, and nNOS in cells. Conclusion. EsA improved intestinal motility and suppressed inflammatory response in DSS-induced UC, which may be mediated by H2S\/CSE and NO\/nNOS systems.<\/jats:p>","DOI":"10.1155\/2022\/7757833","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T21:50:11Z","timestamp":1661982611000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Esculentoside A Alleviates Intestinal Dysmotility in Ulcerative Colitis by Regulating H2S\/CSE and NO\/nNOS Systems"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8131-9384","authenticated-orcid":true,"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haicheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2019.02.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0211-1"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000183"},{"key":"5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/j.sempedsurg.2017.10.003","article-title":"Clinical presentation of Crohn\u2019s, ulcerative colitis, and indeterminate colitis: symptoms, extraintestinal manifestations, and disease phenotypes","volume":"26","author":"R. Y. Yangyang","year":"2017","journal-title":"Seminars in Pediatric Surgery"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2018-0036"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-020-02168-y"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.43.43"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15433"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153343"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.06.037"},{"issue":"7","key":"12","first-page":"595","article-title":"Esculentoside reduces expression of Th17 cell-related cytokines in the imiquimod-induced psoriasis-like dermatitis mouse model","volume":"35","author":"R. Lyu","year":"2019","journal-title":"Xi bao yu fen zi mian yi xue za zhi\u2009=\u2009Chinese journal of cellular and molecular immunology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.08.014"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.003"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-611-5_7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614548096"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw162"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212572"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.37"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236008"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.4.439"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6241"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01984.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i3.353"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.06.053"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2013.2402"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.10.019"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.12.011"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704858"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7757833.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7757833.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/7757833.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T21:50:15Z","timestamp":1661982615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/7757833\/"}},"subtitle":[],"editor":[{"given":"Shoib","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":29,"alternative-id":["7757833","7757833"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7757833","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}