{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:35:15Z","timestamp":1775129715097,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi Sankyo Co. 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The 3 cases presented here summarize a combination approach (surgery+pexidartinib [tyrosine kinase inhibitor]) in patients with previously unresectable or inoperable D-TGCT. Case 1-Hip. A 29-year-old male was treated with pexidartinib prior to surgery, resulting in tumor reduction. A left total hip arthroplasty (THA) was then performed with a lack of recurrence in 12 months postoperative, and the patient currently on pexidartinib treatment. Case 2-Foot. A 35-year-old female, nearly a decade following a left foot mass resection, was treated with pexidartinib following disease recurrence. A decrease in soft tissue lesions at the midfoot and decreased marrow enhancement at the first metatarsal head were seen within 4\u20135 months of pexidartinib treatment; the patient is currently on pexidartinib (400\u2009mg\/day) with improved symptom control. Case 3-Knee. A 55-year-old male patient received pexidartinib pre- and postoperatively. A reduction in swelling and the size of the popliteal cyst was significant and maintained, with the synovial disease growing when pexidartinib was discontinued. Surgery and adjuvant therapy eliminated the disease as of the last follow-up visit (11 months postoperative). These cases provide a unique perspective based on tumor location, type\/timing of treatment strategy, and patient outcomes. Optimal treatment strategies for this debilitating disease may entail utilizing a combination approach (surgery+systemic treatment) to reduce surgical morbidity and the risk of postoperative disease recurrence.<\/jats:p>","DOI":"10.1155\/2022\/7768764","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:05:08Z","timestamp":1670083508000},"page":"1-13","source":"Crossref","is-referenced-by-count":6,"title":["Complementary Effects of Surgery and Pexidartinib in the Management of Patients with Complex Diffuse-Tenosynovial Giant Cell Tumor"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-5878","authenticated-orcid":true,"given":"Nicholas M.","family":"Bernthal","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 1225 15th Street, Suite 2100, Santa Monica, CA, 90404, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-774X","authenticated-orcid":true,"given":"R. Lor","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California, Davis, 4860 Y Street, Suite 3800, Sacramento, CA, 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-1829","authenticated-orcid":true,"given":"Lauren N.","family":"Zeitlinger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California, Davis, 4860 Y Street, Suite 3800, Sacramento, CA, 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-6465","authenticated-orcid":true,"given":"Erik J.","family":"Geiger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 1225 15th Street, Suite 2100, Santa Monica, CA, 90404, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-1186","authenticated-orcid":true,"given":"John H.","family":"Healey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s13569-018-0101-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-20-00028"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260795"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.04.022"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-015-0385-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.008"},{"key":"7","first-page":"100","article-title":"Tenosynovial giant cell tumour, localized type","volume-title":"In WHO Classification of Tumours of Soft Tissue and Bone","author":"N. de Saint Aubain Somerhausen","year":"2013"},{"key":"8","first-page":"102","article-title":"Tenosynovial giant cell tumors, diffuse type","volume-title":"In WHO Classification of Tumours of Soft Tissue and Bone","author":"N. de Saint Aubain Somerhausen","year":"2013"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6293-x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2017.1361126"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.07.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-019-0099-0"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B8.33608"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2020.1757441"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.11078"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411366"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30764-0"},{"key":"19","volume-title":"Turalio (Pexidartinib) Capsules, for Oral Use Prescribing Information","year":"2022"},{"key":"20","volume-title":"NCCN clinical practice guidelines in oncology: soft tissue sarcoma\u2014version 2.2022. The full soft-tissue sarcoma guidelines were obtained from the NCCN website via login\/password","year":"2022"},{"key":"21","volume-title":"FDA approves first therapy for rare joint tumor media release","author":"Food and Drug Administration","year":"2019"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S345878"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13629"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-1475"}],"container-title":["Case Reports in Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2022\/7768764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2022\/7768764.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crior\/2022\/7768764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:05:12Z","timestamp":1670083512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crior\/2022\/7768764\/"}},"subtitle":[],"editor":[{"given":"Taketoshi","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,3]]},"references-count":24,"alternative-id":["7768764","7768764"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7768764","relation":{},"ISSN":["2090-6757","2090-6749"],"issn-type":[{"value":"2090-6757","type":"electronic"},{"value":"2090-6749","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,3]]}}}