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Notably, Zn\u2010based medicinal products play a prominent role in reducing disease symptoms and acute side effects of patients with bone\u2010related diseases. In this study, we report the clinical efficiency of gelatin\u2010 (Gel\u2010) coated ZnO\u2010ZnS core\u2010shell nanoparticles (CSNPs) with umbelliferon (Uf) drug (Uf\u2010Gel\u2010ZnO\u2010ZnS CSNPs) on the normal and CIA\u2010induced Wistar rats. The formed ZnO\u2010ZnS CSNPs are spherical in shape, with an average particle diameter of 150 \u00b1 7\u2009nm. It showed strong cytocompatibility when tested on L929 and foreskin fibroblasts (BJ) cells by MTT assay. While comparing with free Uf, various doses (2.5 and 5\u2009mg) of Uf\u2010Gel\u2010ZnO\u2010ZnS CSNPs showed strong inhibition of CIA by attenuated proinflammatory cytokines such as interleukin\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, PEG2, and IL\u201017. The Uf\u2010Gel\u2010ZnO\u2010ZnS CSNPs show more effectiveness in reducing joint swelling and also increase the level of antioxidant enzymes. In addition, CSNPs significantly reduced the infiltration of inflammatory cells in the knee joint. Thus, the current study concludes that Uf\u2010Gel\u2010ZnO\u2010ZnS CSNPs feasibly reduce the incidence of arthritis in a dose\u2010dependent manner by attenuation of inflammation.<\/jats:p>","DOI":"10.1155\/2022\/7795602","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T20:35:14Z","timestamp":1649277314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dose\u2010Dependent Efficacy of Umbelliferone and Gelatin\u2010Coated ZnO\/ZnS Core\u2010Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee 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