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In recent years, diagnostic techniques have constantly improved with the emergence of more reliable and valid questionnaires as well as more accurate equipment for saliva flow rate measurement and imaging methods. Preventive measures such as the antioxidant MitoTEMPO, botulinum toxin (BoNT), and growth factors have been successfully applied in animal experiments, resulting in positive outcomes. Interventions, such as the new delivery methods of pilocarpine, edible saliva substitutes, acupuncture and electrical stimulation, gene transfer, and stem cell transplantation, have shown potential to alleviate or restore xerostomia in patients. The review summarizes the existing and new diagnostic methods for xerostomia, along with current and potential strategies for reducing IR-induced damage to SG function. We also aim to provide guidance on the advantages and disadvantages of the diagnostic methods. Additionally, most prevention and treatment methods remain in the stage of animal experiments, suggesting a need for further clinical research, among which we believe that antioxidants, gene transfer, and stem cell transplantation have broad prospects.<\/jats:p>","DOI":"10.1155\/2022\/7802334","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T02:35:27Z","timestamp":1661654127000},"page":"1-15","source":"Crossref","is-referenced-by-count":14,"title":["Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yanli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dental Materials, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 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