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Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.<\/jats:p>","DOI":"10.1155\/2022\/7805900","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:50:20Z","timestamp":1661478620000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition"],"prefix":"10.1155","volume":"2022","author":[{"given":"Alena","family":"Str\u00fd\u010dkov\u00e1","sequence":"first","affiliation":[{"name":"National Centre of Hemostasis and Thrombosis, Department of Hematology and Blood Transfusion, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia"},{"name":"Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, 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