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When ROS exceeds the body\u2019s natural antioxidants, the retina is in a state of oxidative stress, which is recognized as the pathogenesis of retinal diseases. The early stage of the pathogenic process is an adaptive change in which oxidative stress and endogenous defense mechanisms occur. If no treatment is applied, the retinal diseases will progress to the pathological stage with neuronal and vascular dysfunction or damage and even blindness. This review summarizes the role of oxidative stress in several common retinal diseases, including retinitis pigmentosa, age\u2010related macular degeneration, diabetic retinopathy, glaucoma, and retinopathy of prematurity. In addition, we discuss the early intervention strategies for these diseases. An outline is provided to identify potential intervention targets for further research. Early intervention for retinal diseases is necessary and urgent and may offer hope to improve patients\u2019 quality of life through functional vision.<\/jats:p>","DOI":"10.1155\/2022\/7836828","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T18:50:33Z","timestamp":1665773433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Role of Oxidative Stress in Retinal Disease and the Early Intervention Strategies: A Review"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-6652","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadullah","family":"Khattak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-8437","authenticated-orcid":false,"given":"Dongdong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-6375","authenticated-orcid":false,"given":"Yalong","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23583"},{"key":"e_1_2_7_2_2","first-page":"315","article-title":"Free radicals and antioxidants: physiology, human pathology and therapeutic aspects (part II)","volume":"53","author":"Sahnoun Z.","year":"1998","journal-title":"Th\u00e9rapie"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108255"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30425-3"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.10.016"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081583"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.16.070196.000341"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9829176"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351147"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.106.077073"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(85)90001-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2020.04.002"},{"key":"e_1_2_7_15_2","first-page":"50","article-title":"Inhibitory effects of tea polyphenols and vitamin C on lipid peroxidation induced by FeSO4- cysteine in isolated human plasma and carbon tetrachloride-induced liver free radical injury in mice","volume":"14","author":"Zhang Q. 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