{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:19:07Z","timestamp":1780381147692,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:p>Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia. Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems. This is of particular significance in Sub-Saharan Africa where helminthic infections are a more prevalent cause of eosinophilia. To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian. He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly. Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor. Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.<\/jats:p>","DOI":"10.1155\/2022\/7841310","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T02:50:06Z","timestamp":1671245406000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Chronic Eosinophilic Leukemia Presenting as Cardiac Failure"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-1396","authenticated-orcid":true,"given":"Nii","family":"Boi-Doku Pepra-Ameyaw","sequence":"first","affiliation":[{"name":"Department of Haematology, Korle Bu Teaching Hospital, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-1950","authenticated-orcid":true,"given":"William Kwasi","family":"Ghunney","sequence":"additional","affiliation":[{"name":"Ghana Institute of Clinical Genetics, Korle Bu, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-6127","authenticated-orcid":true,"given":"Eugene","family":"Baafi Ampofo","sequence":"additional","affiliation":[{"name":"National Cardiothoracic Centre, Korle Bu Teaching Hospital, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-4470","authenticated-orcid":true,"given":"Edeghonghon","family":"Olayemi","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Ghana Medical School, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544.2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26352"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0787"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050054"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-10-200305200-00010"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.05.024"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199402243300804"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.04.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.12.1188"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3737"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa025217"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1627"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8906"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11420"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/7841310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/7841310.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/7841310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T02:50:09Z","timestamp":1671245409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2022\/7841310\/"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":16,"alternative-id":["7841310","7841310"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7841310","relation":{},"ISSN":["2090-6579","2090-6560"],"issn-type":[{"value":"2090-6579","type":"electronic"},{"value":"2090-6560","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,16]]}}}