{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:23:51Z","timestamp":1764937431215,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, China","award":["2020B121201004","2019JC05Y361","2021A1515011146"],"award-info":[{"award-number":["2020B121201004","2019JC05Y361","2021A1515011146"]}]},{"name":"Guangdong Provincial Major Talents Project, China","award":["2020B121201004","2019JC05Y361","2021A1515011146"],"award-info":[{"award-number":["2020B121201004","2019JC05Y361","2021A1515011146"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020B121201004","2019JC05Y361","2021A1515011146"],"award-info":[{"award-number":["2020B121201004","2019JC05Y361","2021A1515011146"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:p>Background. Little is known about the relation between perioperative inflammatory changes and long-term survival in cancer patients. The aim of the study was to assess the association of perioperative serum interleukin-6 (IL6) and tumor necrosis factor-\u03b1 (TNF\u03b1) levels with the 5-year overall survival in locally advanced gastric cancer. Methods. The 135 eligible patients in one center of Nanfang Hospital were retrieved from CLASS-01 trial (NCT01609309), an open-label, multicenter, randomized clinical noninferiority trial conducted at 14 centers in China. Serum IL6 and TNF\u03b1 levels were tested before surgery, and on postoperative day (POD) 1, POD3, and POD5, respectively, referring to IL6_0, IL6_1, IL6_3, and IL6_5 and TNF\u03b1_0, TNF\u03b1_1, TNF\u03b1_3, and TNF\u03b1_5. Kaplan-Meier methods and COX models were used for survival analysis. Results. High levels of IL6_0 (\u22653.67\u2009pg\/mL) and TNF\u03b1_0 (\u226514.8\u2009pg\/mL) presented worse disease-free survival (DFS) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.0057<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> for IL6_0 and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.0014<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula> for TNF\u03b1_0) and overall survival (OS) (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.0021<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> for IL6_0 and <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.0019<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> for TNF\u03b1_0). Both high IL6_0 and high IL6_5 levels indicated worse prognosis than other combinations (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.0045<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula> for DFS and <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.0022<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula> for OS). In multivariate analysis, both high IL6_0 and high IL6_5 levels were significantly associated with poor DFS (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>HR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>4.29<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, 95% CI: 1.42-12.95, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.01<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) and OS (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mtext>HR<\/q:mtext>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>4.11<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>, 95% CI: 1.35-12.49, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.013<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>) after adjustment of tumor stage and TNF\u03b1_0. Also, high IL6_5 level was identified as the independent-related factor for postoperative infectious complications (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mtext>OR<\/u:mtext>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>2.69<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>, 95% CI: 1.03-7.01, <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>P<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.043<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>). Conclusions. Perioperative high serum IL6 and TNF\u03b1 levels are negatively associated with 5-year survival outcomes in patients with locally advanced gastric cancer, indicating the potential survival benefits from perioperative anti-inflammatory treatment.<\/jats:p>","DOI":"10.1155\/2022\/7863480","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T14:35:15Z","timestamp":1657290915000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Perioperative Interleukin-6 and Tumor Necrosis Factor-\u03b1 on Long-Term Outcomes in Locally Advanced Gastric Cancer: Results from the CLASS-01 Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7686-8082","authenticated-orcid":true,"given":"Zhenzhan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 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