{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:45Z","timestamp":1787017785571,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T00:00:00Z","timestamp":1662768000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974126"],"award-info":[{"award-number":["81974126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974123"],"award-info":[{"award-number":["81974123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018YFA0800801"],"award-info":[{"award-number":["2018YFA0800801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["81974126"],"award-info":[{"award-number":["81974126"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["81974123"],"award-info":[{"award-number":["81974123"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFA0800801"],"award-info":[{"award-number":["2018YFA0800801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,9,10]]},"abstract":"<jats:p>\n                    Sclerostin is a secreted inhibitor of Wnt\/\u03b2-catenin signaling that is mainly produced by osteocytes and is an important regulator of bone remodeling. Some studies have evaluated serum sclerostin levels in metabolic bone diseases, but the results have been contradictory. The profile of serum sclerostin levels in patients with osteogenesis imperfecta (OI), X-linked hypophosphatemia (XLH), and Paget\u2019s disease of bone (PDB) was obtained to determine their association with bone turnover marker. Serum sclerostin levels, biochemical parameters, and the bone turnover marker, \u03b2-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (\u03b2-CTX), were measured in 278 individuals, comprising 71 patients with OI, 51 patients with XLH, 17 patients with PDB, and 139 age- and sex-matched healthy controls. A correlation analysis was performed between sclerostin and \u03b2-CTX concentration. The univariate logistic regression analysis was used to analyze factors associated with OI, XLH, and PDB. Patients with PDB (11 male 6 female), aged\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>44.47<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>14.75<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    years; XLH (17 male, 34 female), aged\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>19.29<\/c:mn>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>15.65<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    years; and OI (43 male, 28 female),\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>aged<\/e:mtext>\n                        <e:mtext>\u2009<\/e:mtext>\n                        <e:mn>19.57<\/e:mn>\n                        <e:mo>\u00b1<\/e:mo>\n                        <e:mn>16.45<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    years, had higher sclerostin level than age- and sex-matched healthy controls [median(interquartile range): 291.60 (153.42, 357.35) vs. 38.00 (27.06, 68.52) pmol\/L, 163.40 (125.10, 238.20) vs. 31.13 (20.37, 45.84) pmol\/L, and 130.50 (96.12, 160.80) vs. 119.00 (98.89, 194.80) pmol\/L, respectively;\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ]. Patients with PDB had the highest level of serum sclerostin, followed by those with XLH and OI (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Sclerostin was positively correlated with \u03b2-CTX in OI and XLH (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>r<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.541<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    and\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>r<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.661<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    , respectively;\n                    <jats:inline-formula>\n                      <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>&lt;<\/o:mo>\n                        <o:mn>0.001<\/o:mn>\n                      <\/o:math>\n                    <\/jats:inline-formula>\n                    ). Higher \u03b2-CTX and sclerostin levels were associated with a higher risk of OI, XLH, and PBD. Sclerostin may be a biomarker of OI, XLH, and PDB. Whether sclerostin inhibitors can be used in these patients requires further analysis using additional cohorts.\n                  <\/jats:p>","DOI":"10.1155\/2022\/7902046","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T15:50:35Z","timestamp":1662825035000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Serum Sclerostin and Its Association with Bone Turnover Marker in Metabolic Bone Diseases"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9767-8728","authenticated-orcid":true,"given":"Lihui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7722-115X","authenticated-orcid":true,"given":"Gao","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-0770","authenticated-orcid":true,"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-5894","authenticated-orcid":true,"given":"Hua","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7807-7695","authenticated-orcid":true,"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tsai, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-1617","authenticated-orcid":true,"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.007"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.10.005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113439"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16051-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0152-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.617738"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.06.010"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3852"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3501-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3312"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2244"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.04.016"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3497-1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-020-01163-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2086"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00526-z"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab579"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4791"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH704>3.0.CO;2-U"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900571"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0067"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.12.004"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1669-z"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.345"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4133"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025900"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00057"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2106"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0299"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115465"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00655-5"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.04.011"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3143"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116201"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3923"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.01.012"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.05.005"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/513925"}],"container-title":["Disease 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M.","family":"Kushnir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,10]]},"references-count":38,"alternative-id":["7902046","7902046"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7902046","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,10]]}}}