{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:18:56Z","timestamp":1773872336674,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2022,5,14]]},"abstract":"<jats:p>Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. A total of thirty LDH adults presenting L4 and\/or L5 root (s) compression syndromes (LDH group) and thirty age-, sex-, BMI- and education-matched healthy control (HC group) were recruited for functional MRI scan. Whole-brain functional network was constructed for each participant using Pearson\u2019s correlation. Global and nodal properties were calculated and compared between two groups, including small-worldness index, clustering coefficient, characteristic path length, degree centrality (DC), betweenness centrality (BC) and nodal efficiency. Both LDH and HC groups showed small-world architecture in the functional network of brain. However, LDH group showed that nodal centralities (DC, BC and nodal efficiency) increased in opercular part of inferior frontal gyrus; and decreased in orbital part of inferior frontal gyrus, lingual cortex and inferior occipital gyrus. The DC and efficiency in the right inferior occipital gyrus were negatively related with the Oswestry Disability Index in LDH group. In conclusion, the LDH-related chronic sciatica syndromes may induce regional brain alterations involving self-referential, emotional responses and pain regulation functions. But the whole-brain small-world architecture was not significantly disturbed. It may provide new insights into LDH patients with radicular symptoms from new perspectives.<\/jats:p>","DOI":"10.1155\/2022\/7912410","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T21:20:08Z","timestamp":1652563208000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-3077","authenticated-orcid":true,"given":"Yan-Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Renhe Hospital, Baoshan District, Shanghai 200431, China"},{"name":"Department of Orthopedics, Affiliated Renhe Hospital of Shanghai University, Shanghai 200431, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-9282","authenticated-orcid":true,"given":"Guang-Hui","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fujian 350005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-2398","authenticated-orcid":true,"given":"Chuan-Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Renhe Hospital, Baoshan District, Shanghai 200431, China"},{"name":"Department of Orthopedics, Affiliated Renhe Hospital of Shanghai University, Shanghai 200431, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.6.656"},{"issue":"10289","key":"2","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","article-title":"Chronic pain: an update on burden, best practices, and new advances","volume":"397","author":"S. 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