{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:52:09Z","timestamp":1747191129192,"version":"3.40.5"},"reference-count":112,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Information on Traditional Chinese Medicine","award":["ZZ150314"],"award-info":[{"award-number":["ZZ150314"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,25]]},"abstract":"<jats:p>Background. A malignant tumor is one of the refractory diseases that threaten human life and health. HuoxueHuayu therapy (one of the Traditional Chinese Medicine therapies to promote blood circulation and remove blood stasis) is widely used as an antitumor supplementary method. However, its efficacy and safety are still controversial. Therefore, the objective of this study was to provide evidence-based evidence for HuoxueHuayu therapy in the treatment of malignant tumors and confirm its safety and effectiveness. Methods. A systematic search in 8 electronic databases targeted randomized clinical studies evaluating HuoxueHuayu therapy for response evaluation, tumor progression rate, quality of life (QoL), peripheral hemogram, performance status, immunologic function, tumor marker, and blood coagulation function in cancer patients, published from the establishment of the database to December 31, 2020. Risk ratio (RR) was used for counting data, mean difference (MD) or standardized mean difference (SMD) was used for measurement data, and 95% confidence interval (CI) was used as efficacy analysis statistics. Results. Our search identified 69 studies, evaluating 4402 patients in total. Randomized controlled trials (RCTs) evaluated gastric (n\u2009=\u200914), lung (n\u2009=\u200918), pancreatic (n\u2009=\u20092), colorectal (n\u2009=\u200910), liver (n\u2009=\u200914), breast (n\u2009=\u20092), ovarian (n\u2009=\u20092), gallbladder (n\u2009=\u20091), esophagus (n\u2009=\u20091), and combined (n\u2009=\u200914) cancers and hematological malignancies (n\u2009=\u20092). The duration of HuoxueHuayu therapy ranged from 3 to 48 weeks. Methodological bias was low in 64 studies and high in 5 studies. HuoxueHuayu therapy was associated with significant improvement in response evaluation (Response Evaluation Criteria in Solid Tumor (RECIST): RR: 1.44, 95% CI: 1.27 to 1.63, I2\u2009=\u20090%, n\u2009=\u200933 studies; World Health Organization Criteria in Solid Tumors (WHOCIST): RR: 1.40, 95% CI: 1.23 to 1.59, I2\u2009=\u20090%, n\u2009=\u200926 studies), recurrence rate (RR: 0.85, 95% CI: 0.72 to 0.99, I2\u2009=\u20090%, n\u2009=\u20092 studies), quality of life, performance status (MD: 5.60, 95% CI: 5.04 to 6.15, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), immunologic function (CD3: SMD: 1.23, 95% CI: 0.79 to 1.66, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>; CD4: SMD: 1.25, 95% CI: 0.77 to 1.74, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>; CD4\/CD8: SMD: 1.05, 95% CI: 0.69 to 1.42, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>; natural killer cell (NK): SMD: 0.74, 95% CI: 0.32 to 1.15, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), tumor marker, and blood coagulation function (D-dimer (D-D); fibrinogen (FIB)). In addition, HuoxueHuayu therapy could reduce toxicity caused by chemotherapy and radiotherapy without risks of liver and kidney injury or bleeding, although the effect on tumor metastasis was uncertain. Conclusions. The present update of our systematic review and meta-analyses provided essential evidence for the beneficial effect of HuoxueHuayu therapy to show promise in cancer treatment, improving quality of life, addressing cancer-related symptoms, and reducing toxicity in a secure way.<\/jats:p>","DOI":"10.1155\/2022\/7944063","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T20:35:09Z","timestamp":1661459709000},"page":"1-22","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and Safety of the Traditional Chinese Medicine Treatment (HuoxueHuayu Therapy) for Malignant Tumors: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-1126","authenticated-orcid":true,"given":"Zehui","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-9061","authenticated-orcid":true,"given":"An","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wei","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Li","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.639514"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040945"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.7150\/jca.53115"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01615-z"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s273794"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4217529"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072165"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113041"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(13)60095-3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092187"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183218"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-009-0395-2"},{"issue":"5","key":"14","first-page":"4591","article-title":"Qi Ling decoction reduces gastric cancer cell metastasis by inhibiting MMP-9 through the PI3KAkt signaling pathway","volume":"13","author":"W. 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