{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:52:49Z","timestamp":1769525569173,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,8,8]]},"abstract":"<jats:p>Objective. The cardiac safety of concurrent treatment with anthracycline (A), cyclophosphamide (C), and paclitaxel (T) in an adjuvant BC treatment regimen is still under debate. In this study, we aimed to determine cardiotoxicity events following ACT chemotherapy among operable breast cancer patients without HER2-positive. Methods. We searched PubMed and the Cochrane Library for RCTs prior to July 2019 evaluating the cardiac impairment of ACT chemotherapy regimens in BC patients. The search terms were \u201cBC,\u201d \u201cchemotherapy,\u201d \u201cdocetaxel or \u201cdoxorubicin,\u201d \u201cpaclitaxel,\u201d and \u201ccyclophosphamide.\u201d Cardiotoxic events included LVEF <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>decline<\/a:mtext>\n                        <a:mo>\u2265<\/a:mo>\n                        <a:mn>10<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> points, congestive heart failure (CHF), and cardiac death. Results. In total, 12 studies with 4032 subjects were included in this meta-analysis, and all patients received ACT regimen. The analysis results indicated that LVEF <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>decrease<\/c:mtext>\n                        <c:mo>\u2265<\/c:mo>\n                        <c:mn>10<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula> points was the most common cardiotoxic event (16%; (95% CI (8%\u201324%)) with <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:msup>\n                           <e:mrow>\n                              <e:mi>\u03c7<\/e:mi>\n                           <\/e:mrow>\n                           <e:mrow>\n                              <e:mn>2<\/e:mn>\n                           <\/e:mrow>\n                        <\/e:msup>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>95.75<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:msup>\n                           <i:mrow>\n                              <i:mi>I<\/i:mi>\n                           <\/i:mrow>\n                           <i:mrow>\n                              <i:mn>2<\/i:mn>\n                           <\/i:mrow>\n                        <\/i:msup>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>95.8<\/i:mn>\n                        <i:mi>%<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>). CHF showed the lowest rate (1%; (95% CI (0%\u20131%)) with <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:msup>\n                           <k:mrow>\n                              <k:mi>\u03c7<\/k:mi>\n                           <\/k:mrow>\n                           <k:mrow>\n                              <k:mn>2<\/k:mn>\n                           <\/k:mrow>\n                        <\/k:msup>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>8.00<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.433<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:msup>\n                           <o:mrow>\n                              <o:mi>I<\/o:mi>\n                           <\/o:mrow>\n                           <o:mrow>\n                              <o:mn>2<\/o:mn>\n                           <\/o:mrow>\n                        <\/o:msup>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.0<\/o:mn>\n                        <o:mi>%<\/o:mi>\n                     <\/o:math>\n                  <\/jats:inline-formula>). Subgroup analysis demonstrated that the incidence of CHF due to A\u2009\u2192\u2009C\u2009\u2192\u2009T chemotherapy regimen was lower than that of other events, however, without significance. No significant difference was observed in the occurrence of cardiac death. Conclusion. The ACT regimen in patients with HER2-negative BC was associated with an increased risk of adverse cardiactoxic events.<\/jats:p>","DOI":"10.1155\/2022\/7963146","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T05:20:10Z","timestamp":1660022410000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Grading Evaluation of Cardiotoxicity in Patients with Breast Cancer Treated with Adjuvant Paclitaxel Anthracycline\/Cyclophosphamide Chemotherapy: A Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Weibao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Fifth People\u2019s Hospital of Shangrao City, Jiangxi Province, Shangrao 334099, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengli","family":"Song","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial People\u2019s Hospital Affiliated to Nanchang University, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-3993","authenticated-orcid":true,"given":"Linfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiangxi Provincial People\u2019s Hospital, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21565"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19323"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309890.127"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01262"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2008.01.008"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1587829"},{"issue":"6","key":"7","first-page":"1511","article-title":"Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium","volume":"7","author":"G. Minotti","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/1389200216666151103114926"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-013-9681-6"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.07.031"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-015-1362-x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-05114-7"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0796-0"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.05.017"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09808-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.74.1165"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1999.17.1.93"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910383"},{"key":"19","first-page":"1646","article-title":"Influence factors for early cardiac toxicity in patients with brease cancer undergoing chemotherapy with epirubicin regimens","volume":"40","author":"F. Yanying","year":"2014","journal-title":"Jiangsu Medical Journal"}],"updated-by":[{"DOI":"10.1155\/2023\/9783196","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"record-id":"54975"},{"DOI":"10.1155\/2023\/9783196","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/7963146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/7963146.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/7963146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T05:20:14Z","timestamp":1660022414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/7963146\/"}},"subtitle":[],"editor":[{"given":"Ahmed Faeq","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":19,"alternative-id":["7963146","7963146"],"URL":"https:\/\/doi.org\/10.1155\/2022\/7963146","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9783196","asserted-by":"object"}]},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,8]]}}}