{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:05:48Z","timestamp":1790791548556,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"The goal of this study was to see how important it is to monitor Mycoplasma pneumoniae-specific antibody IgM, C-reactive protein, and procalcitonin levels in the blood of kids with Mycoplasma pneumoniae pneumonia as a reference for clinical diagnosis and treatment. The study group consisted of 96 children who had mycoplasma pneumonia in our hospital between May 2020 and May 2021, and the control group consisted of 96 healthy children who had a routine physical examination in our hospital at the same time. C-reactive protein and procalcitonin were measured and compared. The application value of single detection and combined detection of Mycoplasma pneumoniae-specific antibody IgM, C-reactive protein, and procalcitonin in the diagnosis of Mycoplasma pneumoniae pneumonia was evaluated based on clinical diagnosis results. The detection values of C-reactive protein and procalcitonin in the study group were higher than those in the recovery period and the control group, \n \n P<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>; the detection values of C-reactive protein and procalcitonin in the study group were higher than those in the control group, \n \n P<\/c:mi>\n <<\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>. The combination detection of Mycoplasma pneumoniae-specific antibody IgM, C-reactive protein, and procalcitonin had a greater diagnostic accuracy than single detection (\n \n P<\/e:mi>\n <<\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>). The sensitivity was higher than C-reactive protein and procalcitonin (\n \n P<\/g:mi>\n <<\/g:mo>\n 0.05<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>); the specificity and positive predictive value were higher than Mycoplasma pneumoniae-specific antibody IgM (\n \n P<\/i:mi>\n <<\/i:mo>\n 0.05<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>); and the negative predictive value was higher than procalcitonin (\n \n P<\/k:mi>\n <<\/k:mo>\n 0.05<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>). The clinical value of combining the detection of Mycoplasma pneumoniae-specific antibody IgM, C-reactive protein, and procalcitonin in the diagnosis of Mycoplasma pneumoniae pneumonia in children is higher than that of single item detection, and it can provide a reliable clinical reference, as well as aid in evaluating the recovery effect of children, and it is worthy of application.<\/jats:p>","DOI":"10.1155\/2022\/7976858","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T23:13:11Z","timestamp":1656457991000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Monitoring Mycoplasma pneumoniae-Specific Antibody, C-Reactive Protein, and Procalcitonin Levels in Children with Mycoplasma Pneumonia Is Important"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-0423","authenticated-orcid":true,"given":"Xinying","family":"Cao","sequence":"first","affiliation":[{"name":"School of Harbin Medical University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"108","article-title":"Expression of Th17 and Treg cell subsets and cytokines in peripheral blood of children with Mycoplasma pneumoniae and study on CRP and PCT levels","volume":"34","author":"T. 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Haifeng","year":"2017","journal-title":"Heilongjiang Medicine Journal"},{"issue":"8","key":"18","first-page":"1075","article-title":"Clinical value of serum amyloid a combined with procalcitonin, C-reactive protein and leucocyte count in the diagnosis of lower respiratory tract infection in children","volume":"47","author":"B. Julin","year":"2018","journal-title":"Shaanxi Medical Journal"},{"issue":"7","key":"19","first-page":"1","article-title":"Changes of Mycoplasma pneumoniae antibody titer and C-reactive protein in children with segmental pneumonia","volume":"25","author":"W. Xiaobin","year":"2019","journal-title":"Journal of Pediatric Pharmacy"},{"issue":"5","key":"20","first-page":"574","article-title":"Application value of procalcitonin, high-sensitivity C-reactive protein and leukocyte count in early diagnosis of acute respiratory tract infection in children","volume":"31","author":"H. Lizhen","year":"2020","journal-title":"Journal of Aerospace medicine"},{"issue":"14","key":"21","first-page":"1719","article-title":"Diagnosis value of serum procalcitonin in children with upper respiratory tract infection","volume":"28","author":"Q. Hairong","year":"2018","journal-title":"Chinese Journal of Health Laboratory Technology"},{"issue":"2","key":"22","first-page":"57","article-title":"Effect of budesonide atomization inhalation combined with azithromycin in the treatment of mycoplasma pneumonia in children","volume":"21","author":"L. Zhongzheng","year":"2022","journal-title":"Journal of Anhui Medical College"},{"issue":"10","key":"23","first-page":"64","article-title":"Effects of montelukast sodium on serum interleukin, sB7-H3 and IFN-\u03b3, GM-CSF expression Contemporary medicine","volume":"28","author":"Z. 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