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The available peroxisomal gene\u2010knockout female mouse models, which exhibit pathological changes in the ovary and reduced fertility, are listed in this review. Our review article provides the first systematic presentation of peroxisomal regulation and its possible functions in the ovary. Our immunofluorescence results reveal that peroxisomes are present in all cell types in the ovary; however, peroxisomes exhibit different numerical abundances and strong heterogeneity in their protein composition among distinct ovarian cell types. The peroxisomal compartment is strongly altered during follicular development and during oocyte maturation, which suggests that peroxisomes play protective roles in oocytes against oxidative stress and lipotoxicity during ovulation and in the survival of oocytes before conception. In addition, the peroxisomal compartment is involved in steroid synthesis, and peroxisomal dysfunction leads to disorder in the sexual hormone production process. However, an understanding of the cellular and molecular mechanisms underlying these physiological and pathological processes is lacking. To date, no effective treatment for peroxisome\u2010related disease has been developed, and only supportive methods are available. Thus, further investigation is needed to resolve peroxisome deficiency in the ovary and eventually promote female fertility.<\/jats:p>","DOI":"10.1155\/2022\/7982344","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:20:07Z","timestamp":1643934007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Key Role of Peroxisomes in Follicular Growth, Oocyte Maturation, Ovulation, and Steroid Biosynthesis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-5517","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2463-0766","authenticated-orcid":false,"given":"HaoXuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-3396","authenticated-orcid":false,"given":"YongLun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3810-4027","authenticated-orcid":false,"given":"XiaoMing","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-7278","authenticated-orcid":false,"given":"ChiChiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-229X","authenticated-orcid":false,"given":"WenMing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.2.0394"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-66"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/21.11.963"},{"key":"e_1_2_14_4_2","first-page":"421","article-title":"Changes in catalase activity and hydrogen peroxide level in rat ovary during estrous cycle and induction of catalase in rat ovary by estradiol-17 beta","volume":"36","author":"Singh D.","year":"1998","journal-title":"Indian Journal of Experimental Biology"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)02056-4"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2926"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.08.016"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(98)00003-X"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199509000-00015"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00602.x"},{"key":"e_1_2_14_11_2","first-page":"181","article-title":"Adreno-leukodystrophy (adreno-testiculo-leukomyelo-neuropathic-complex)","volume":"4","author":"Powers J. 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