{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:59:43Z","timestamp":1771329583348,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Aging is a complex process often associated with a chronic inflammatory profile that alters several biological functions, including the immune system and cognitive and physical capacity. The practice of physical activity is increasingly gaining popularity as a method of preventing infections, depression, and other disorders that affect the quality of life of the elderly. Thus, this work analyzes the profile of cytokines and molecular markers expressed in immune cells of elderly people who practice physical activities or not, evaluating their impacts on the immune system and quality of life. For this, 48 individuals were recruited, and peripheral blood samples were collected for hemogram analysis, cytokine determination, and immunophenotyping. Elderly people were separated into two groups: practitioners with low\u2010intensity physical activity and non\u2010practitioners. Quality of life was assessed using the Whoqol\u2010Old instrument, and depression was assessed using the Beck II Depression Inventory. When comparing the scores of the Whoqol\u2010Old and Beck questionnaires, we observed a significant negative correlation between these two factors. The perception of a higher quality of life was present in the elderly who exercised and was related to greater autonomy and sensory abilities, whereas the presence of depression was lower. In the hemogram, we observed higher basophil and segmented counts in the sedentary elderly, whereas lymphocytes and monocytes had lower counts. Elderly practitioners of physical activities had higher levels of IFN\u2010<jats:italic>\u03b3<\/jats:italic>, IL\u20104, and IL\u201010; increased expression of CD69, PD1, and TIM\u20103 in CD4+ T lymphocytes and increased CD14+CD80+ and CD14+CD86+ monocytes. Elderly people with an increased perception of quality of life had higher levels of IFN\u2010<jats:italic>\u03b3<\/jats:italic>, higher expression of CD14+CD80+CD86+, and decreased levels of TRAIL. An increase in TRAIL was observed in individuals with depression, in addition to an increased expression of CD14+CD86+. These results show a clear correlation between the quality of life, level of depression, physical activity, and immune system function. Although some cytokines with a typical proinflammatory profile (IFN\u2010<jats:italic>\u03b3<\/jats:italic>) were observed, the results point to a protective state with benefits reflected in the general well\u2010being of the elderly who exercise.<\/jats:p>","DOI":"10.1155\/2022\/7985596","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T22:20:14Z","timestamp":1663885214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immunophenotypic Analysis of T Lymphocytes and Cytokine Production in Elderly Practicing Physical Activities and Its Relationship with Quality of Life and Depression"],"prefix":"10.1155","volume":"2022","author":[{"given":"Tamires Marielem","family":"de Carvalho-Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-5112","authenticated-orcid":false,"given":"Jos\u00e9 Rodrigues","family":"do Carmo Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Gl\u00f3ria Fonseca","family":"Teodoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Zero","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Pimenta","family":"Rochael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Farnesi Soares","family":"de Assun\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Coutinho","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Sodr\u00e9","family":"Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Degani Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djalma Alexandre Alves","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-7788","authenticated-orcid":false,"given":"Juliana Reis","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Gomes Salles","family":"Tiburcio-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2211-7333","authenticated-orcid":false,"given":"Carlo Jos\u00e9 Freire","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-4223","authenticated-orcid":false,"given":"Virmondes Rodrigues","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Bertulucci Rocha","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7621","authenticated-orcid":false,"given":"Marcos Vin\u00edcius","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02187"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52308.x"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.5935\/0034-7167.20140060"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-110420151050002020"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102012005000044"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181b7b3d9"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181a0c95c"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06849.x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102006000100011"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-7380-9"},{"key":"e_1_2_10_11_2","volume-title":"Manual for the Beck Depression Inventory-II","author":"Beck A. 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