{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:40Z","timestamp":1790352580909,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:p>The aim of this systematic review was to identify randomized controlled trials that looked at the effects of Nigella sativa in any form on different skin diseases. Up to March 2022, the online databases of Scopus, Web of Science, PubMed, Embase, Google Scholar, and Cochrane trials were searched. This study included 14 records of people who had experienced different types of skin disease including atopic dermatitis, vulgaris, arsenical keratosis, psoriasis, vitiligo, acute cutaneous leishmaniasis, warts, eczema, and acne. The mean SD age of the patients was 28.86 (4.49); [range: 18.3\u201351.4], with females accounting for 69% (506 out of 732) of the total. The follow-up mean SD was 8.16 (1.3) (ranged: 4 days to 24 weeks). The odds ratio (OR) was found to be 4.59 in a meta-analysis (95% CI: 2.02, 10.39). Whereas the null hypothesis in this systematic review was that lotion had no impact, OR 4.59 indicated that lotion could be effective. The efficacy of N. sativa essential oil and extract has been demonstrated in most clinical studies. However, more research is needed to completely evaluate and validate the efficacy or inadequacy of therapy with N. sativa, although it appears that it can be used as an alternative treatment to help people cope with skin problems.<\/jats:p>","DOI":"10.1155\/2022\/7993579","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T23:20:20Z","timestamp":1670282420000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["The Therapeutic Effects of Nigella sativa on Skin Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-0866","authenticated-orcid":true,"given":"Naser","family":"Nasiri","sequence":"first","affiliation":[{"name":"HIV\/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-9033","authenticated-orcid":true,"given":"Mozhde","family":"Ilaghi Nezhad","sequence":"additional","affiliation":[{"name":"Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-3760","authenticated-orcid":true,"given":"Fariba","family":"Sharififar","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-466X","authenticated-orcid":true,"given":"Mahdieh","family":"Khazaneha","sequence":"additional","affiliation":[{"name":"Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-2358","authenticated-orcid":true,"given":"Mohammad Javad","family":"Najafzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-2935","authenticated-orcid":true,"given":"Neda","family":"Mohamadi","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.01.052"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.023"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s1875-5364(16)30088-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.17221\/2948-vetmed"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4197\/sci.21-2.11"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5985207"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.ijpvm_276_18"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2021.03.015"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01271.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-25234"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1356"},{"issue":"3","key":"12","first-page":"444","article-title":"The effect of clove bud, Nigella and Salix alba on wart and comparison with conventional therapy","volume":"21","author":"K. 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