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Salidroside, a major bioactive ingredient extracted from <jats:italic>Rhodiola rosea<\/jats:italic>, has strong antioxidant activity. The purpose of this study was to examine the effect of salidroside on testicular ischemia\u2010reperfusion injury. Sixty rats were randomly separated into 3 experimental groups: group A = sham\u2010operated control; group B = testicular ischemia\u2010reperfusion; and group C = testicular ischemia\u2010reperfusion treated with salidroside. The rats in the sham\u2010operated control group received all surgical procedures except testicular torsion\u2010detorsion. The testicular ischemia\u2010reperfusion group underwent 2 hours of left testicular torsion followed by detorsion. The rats in the salidroside\u2010treated group received the same surgical procedure as in testicular ischemia\u2010reperfusion group, but salidroside was injected intraperitoneally at reperfusion. Testicular malondialdehyde content (a reliable index of reactive oxygen species) and protein expression of superoxide dismutase and catalase which are primary antioxidant enzymes in testes were measured at 4 hours after reperfusion. Testicular spermatogenesis was evaluated at 3 months after reperfusion. The malondialdehyde content increased significantly, while superoxide dismutase and catalase protein expression and testicular spermatogenesis reduced significantly in ipsilateral testes of testicular ischemia\u2010reperfusion group, as compared with sham\u2010operated control group. Therapy with salidroside significantly reduced malondialdehyde content and significantly enhanced superoxide dismutase and catalase protein expression and spermatogenesis in ipsilateral testes, as compared with testicular ischemia\u2010reperfusion group. The present findings indicate that treatment with salidroside ameliorates testicular ischemia\u2010reperfusion injury by reducing reactive oxygen species level by upregulating superoxide dismutase and catalase protein expression.<\/jats:p>","DOI":"10.1155\/2022\/8069152","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T18:51:34Z","timestamp":1652295094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Salidroside Exerts Beneficial Effect on Testicular Ischemia\u2010Reperfusion Injury in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-7110","authenticated-orcid":false,"given":"Si-Ming","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-1589","authenticated-orcid":false,"given":"Zhi-Quan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.11.034"},{"key":"e_1_2_9_2_2","first-page":"10026","article-title":"An unusual presentation of testicular torsion in children: a single - centre retrospective study","volume":"26","author":"Pogorelic Z.","year":"2019","journal-title":"The Canadian Journal of Urology"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2021.04.017"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.09.10"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079523"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1978.tb02764.x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90090-6"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1986.tb05916.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170711"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13096"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/and.14245"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.10.006"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2004.02.020"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-12"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1530\/ror.0.0020048"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.02.002"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.06.026"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3351-y"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.172317"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.109094"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-021-03307-0"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(21)60043-2"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.11.036"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.635762"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9045-6"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6614574"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145075"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.04.001"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.04.011"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3549704"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9043806"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5424097"},{"key":"e_1_2_9_35_2","first-page":"2","article-title":"Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males","volume":"1","author":"Johnsen S. 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