{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:34:47Z","timestamp":1791387287219,"version":"4.3.3"},"reference-count":376,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Despite the progression in targeting the complex pathophysiological mechanisms of neurodegenerative diseases (NDDs) and spinal cord injury (SCI), there is a lack of effective treatments. Moreover, conventional therapies suffer from associated side effects and low efficacy, raising the need for finding potential alternative therapies. In this regard, a comprehensive review was done regarding revealing the main neurological dysregulated pathways and providing alternative therapeutic agents following SCI. From the mechanistic point, oxidative stress and inflammatory pathways are major upstream orchestras of cross\u2010linked dysregulated pathways (e.g., apoptosis, autophagy, and extrinsic mechanisms) following SCI. It urges the need for developing multitarget therapies against SCI complications. Polyphenols, as plant\u2010derived secondary metabolites, have the potential of being introduced as alternative therapeutic agents to pave the way for treating SCI. Such secondary metabolites presented modulatory effects on neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in the onset and progression of SCI. In the present review, the potential role of phenolic compounds as critical phytochemicals has also been revealed in regulating upstream dysregulated oxidative stress\/inflammatory signaling mediators and extrinsic mechanisms of axonal regeneration after SCI in preclinical and clinical studies. Additionally, the coadministration of polyphenols and stem cells has shown a promising strategy for improving post\u2010SCI complications.<\/jats:p>","DOI":"10.1155\/2022\/8100195","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:08:04Z","timestamp":1641600484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Effects of Polyphenols on Oxidative Stress, Inflammation, and Interconnected Pathways during Spinal Cord Injury"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8265-8284","authenticated-orcid":false,"given":"Sajad","family":"Fakhri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Abbaszadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-3495","authenticated-orcid":false,"given":"Seyed Zachariah","family":"Moradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-4404","authenticated-orcid":false,"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-770X","authenticated-orcid":false,"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142640"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1330"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105069"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i1.24"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-017-0462-z"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.18"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2017"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101483"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.111"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00289-w"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26865"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00512"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00114"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.03.014"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6687493"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00477"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2010.10.016"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4274"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06395.x"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121920"},{"key":"e_1_2_13_22_2","article-title":"Inflammation & apoptosis in spinal cord injury","volume":"135","author":"Zhang N.","year":"2012","journal-title":"The Indian journal of medical research"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.217"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.05.053"},{"key":"e_1_2_13_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.187"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.178"},{"key":"e_1_2_13_27_2","article-title":"Prolonged constriction of sciatic nerve affecting oxidative stressors & antioxidant enzymes in rat","volume":"129","author":"Varija D.","year":"2009","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.12.011"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21257"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.06.016"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9230-2"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3642491"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.05.004"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.012"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.01.015"},{"key":"e_1_2_13_36_2","first-page":"1784","article-title":"Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress\u2013induced retinal ganglion cell death","volume":"17","author":"Nakayama M.","year":"2011","journal-title":"Molecular vision"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.01.055"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.3103\/S009639251804003X"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005786"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.178"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.09.012"},{"key":"e_1_2_13_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01751-2"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.10.006"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01488.x"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25214926"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040762"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00238"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.02.007"},{"key":"e_1_2_13_49_2","first-page":"604","article-title":"Secondary metabolites of plants in drugs discovery","volume":"4","author":"Rungsung W.","year":"2015","journal-title":"World Journal of Pharmaceutical Research"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2005.12.015"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-019-08585-z"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180912105036"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156039"},{"key":"e_1_2_13_55_2","first-page":"120","article-title":"Natural polyphenols and spinal cord injury","volume":"18","author":"Khalatbary A. R.","year":"2014","journal-title":"Iranian biomedical journal"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1997.tb01580.x"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.12096"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0b013e3181ae8959"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.2174\/1876396001104010189"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021972"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.05.007"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2005.22.1475"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0070-9"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0889-x"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0871-5"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162267"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151554"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-9-53"},{"key":"e_1_2_13_69_2","first-page":"303","article-title":"Antioxidation of quercetin against spinal cord injury in rats","volume":"9","author":"Liu J.","year":"2006","journal-title":"Chinese journal of traumatology"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1770265"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26392"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.45"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.23799-18.1"},{"key":"e_1_2_13_74_2","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2016.44575"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.02.016"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201805_14990"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1613-2"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.227"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.12.006"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061297"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-020-01841-1"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.09.006"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-12-52"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1500124"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1473"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.137591"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-82"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0333"},{"key":"e_1_2_13_89_2","first-page":"31","article-title":"Anti-inflammatory effect of the epigallocatechin gallate following spinal cord trauma in rat","volume":"15","author":"Khalatbary A. R.","year":"2011","journal-title":"Iranian biomedical journal"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.109"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6919"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.224379"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.722"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.01.013"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/145342"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80184-V"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2346"},{"key":"e_1_2_13_98_2","article-title":"Antimicrobial activities of caffeic acid phenethyl ester","volume":"4","author":"Meyuhas S.","year":"2015","journal-title":"Journal of Molecular Biochemistry"},{"key":"e_1_2_13_99_2","first-page":"2064","article-title":"The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers","volume":"16","author":"Ozturk G.","year":"2012","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.03.015"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9090"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.33.2028"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.0057"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh316"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00187-9"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.04.002"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150712149"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.07.015"},{"key":"e_1_2_13_109_2","first-page":"20","article-title":"Effects of intrathecal caffeic acid phenethyl ester and methylprednisolone on oxidant\/antioxidant status in traumatic spinal cord injuries","volume":"76","author":"Gocmez C.","year":"2015","journal-title":"Journal of Neurological Surgery Part A: Central European Neurosurgery"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.20011-17.1"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2015.33848"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.32.1"},{"key":"e_1_2_13_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00246-8"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.04.022"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.02.015"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v13i10.11"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2008.00725.x"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.08.014"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.11.020"},{"key":"e_1_2_13_120_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-41334-1_11"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2007.00082.x"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2012.766"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.08182FP"},{"key":"e_1_2_13_124_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4660"},{"key":"e_1_2_13_125_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00290"},{"key":"e_1_2_13_126_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-15"},{"key":"e_1_2_13_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.10.016"},{"key":"e_1_2_13_128_2","first-page":"501","article-title":"Inhibitory effects of phenolics on xanthine oxidase","volume":"14","author":"Chang W.","year":"1994","journal-title":"Anticancer research"},{"key":"e_1_2_13_129_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772466"},{"key":"e_1_2_13_130_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf904207m"},{"key":"e_1_2_13_131_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000758"},{"key":"e_1_2_13_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.08.026"},{"key":"e_1_2_13_133_2","doi-asserted-by":"publisher","DOI":"10.1080\/14786410701591754"},{"key":"e_1_2_13_134_2","doi-asserted-by":"publisher","DOI":"10.3390\/app9153139"},{"key":"e_1_2_13_135_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1568274"},{"key":"e_1_2_13_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.06.042"},{"key":"e_1_2_13_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2374-6"},{"key":"e_1_2_13_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.01.008"},{"key":"e_1_2_13_139_2","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2015.135"},{"key":"e_1_2_13_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.01.001"},{"key":"e_1_2_13_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0920-4"},{"key":"e_1_2_13_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.028"},{"key":"e_1_2_13_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00788.x"},{"key":"e_1_2_13_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2010.00850.x"},{"key":"e_1_2_13_145_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22363"},{"key":"e_1_2_13_146_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/404236"},{"key":"e_1_2_13_147_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0715-x"},{"key":"e_1_2_13_148_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161208786404227"},{"key":"e_1_2_13_149_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2645237"},{"key":"e_1_2_13_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110835"},{"key":"e_1_2_13_151_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02724-5"},{"key":"e_1_2_13_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.90"},{"key":"e_1_2_13_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00461-0"},{"key":"e_1_2_13_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.051"},{"key":"e_1_2_13_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.11.009"},{"key":"e_1_2_13_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.04.025"},{"key":"e_1_2_13_157_2","first-page":"514","article-title":"Comparative study of antioxidant properties and cytoprotective activity of flavonoids","volume":"68","author":"Potapovich A.","year":"2003","journal-title":"Biochemistry"},{"key":"e_1_2_13_158_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082276"},{"key":"e_1_2_13_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2006.05.002"},{"key":"e_1_2_13_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.02.046"},{"key":"e_1_2_13_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.02.041"},{"key":"e_1_2_13_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.05.001"},{"key":"e_1_2_13_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.07.009"},{"key":"e_1_2_13_164_2","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2011.628676"},{"key":"e_1_2_13_165_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01898-w"},{"key":"e_1_2_13_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.12.021"},{"key":"e_1_2_13_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.10.010"},{"key":"e_1_2_13_168_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1690-2"},{"key":"e_1_2_13_169_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-018-0550-5"},{"key":"e_1_2_13_170_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4357"},{"key":"e_1_2_13_171_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.217349"},{"key":"e_1_2_13_172_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2015.1082186"},{"key":"e_1_2_13_173_2","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2020.31832.7657"},{"key":"e_1_2_13_174_2","doi-asserted-by":"publisher","DOI":"10.1590\/acb360307"},{"key":"e_1_2_13_175_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0295-0"},{"key":"e_1_2_13_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.07.051"},{"key":"e_1_2_13_177_2","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22626"},{"key":"e_1_2_13_178_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22283"},{"key":"e_1_2_13_179_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.09.015"},{"key":"e_1_2_13_180_2","first-page":"930","article-title":"Influence of hesperidin combined with Sinemet on genetical and biochemical abnormalities in rats suffering from Parkinson\u2019s disease","volume":"9","author":"Salem H. R. A.","year":"2012","journal-title":"Life Sciences"},{"key":"e_1_2_13_181_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0098-x"},{"key":"e_1_2_13_182_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/249031"},{"key":"e_1_2_13_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.07.037"},{"key":"e_1_2_13_184_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.089"},{"key":"e_1_2_13_185_2","first-page":"7","article-title":"Hesperidin protects against diethylnitrosamine\/carbon tetrachloride-induced renal repercussions via up-regulation of Nrf2\/HO-1 signaling and attenuation of oxidative stress","volume":"7","author":"Aly M. S.","year":"2017","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_13_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134619"},{"key":"e_1_2_13_187_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0326-3"},{"key":"e_1_2_13_188_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6030091"},{"key":"e_1_2_13_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.02.027"},{"key":"e_1_2_13_190_2","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918767549"},{"key":"e_1_2_13_191_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1263597"},{"key":"e_1_2_13_192_2","volume-title":"Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications","author":"De La Lastra C. A.","year":"2007"},{"key":"e_1_2_13_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2016.10.019"},{"key":"e_1_2_13_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.03.015"},{"key":"e_1_2_13_195_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep22859"},{"key":"e_1_2_13_196_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1072-0"},{"key":"e_1_2_13_197_2","first-page":"10420","article-title":"Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2\/ARE pathway","volume":"8","author":"Cheng L.","year":"2015","journal-title":"International journal of clinical and experimental medicine"},{"key":"e_1_2_13_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.07.034"},{"key":"e_1_2_13_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.03.008"},{"key":"e_1_2_13_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.05.001"},{"key":"e_1_2_13_201_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2006.00416.x"},{"key":"e_1_2_13_202_2","first-page":"1237","article-title":"Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs","volume":"8","author":"Liu J.","year":"2015","journal-title":"International journal of clinical and experimental pathology"},{"key":"e_1_2_13_203_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.266064"},{"key":"e_1_2_13_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147079"},{"key":"e_1_2_13_205_2","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2014.44.54"},{"key":"e_1_2_13_206_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8294"},{"key":"e_1_2_13_207_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.792849"},{"key":"e_1_2_13_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.053"},{"key":"e_1_2_13_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.02.006"},{"key":"e_1_2_13_210_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9394150"},{"key":"e_1_2_13_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135262"},{"key":"e_1_2_13_212_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2019.01.015"},{"key":"e_1_2_13_213_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23171"},{"key":"e_1_2_13_214_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-020-00521-4"},{"key":"e_1_2_13_215_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.03.032"},{"key":"e_1_2_13_216_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12301"},{"key":"e_1_2_13_217_2","first-page":"703","article-title":"Effects of resveratrol on secondary damages after acute spinal cord injury in rats","volume":"24","author":"Yang Y.-B.","year":"2003","journal-title":"Acta Pharmacologica Sinica"},{"key":"e_1_2_13_218_2","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies","volume":"23","author":"Aggarwal B. B.","year":"2003","journal-title":"Anticancer research"},{"key":"e_1_2_13_219_2","volume-title":"Antioxidant and anti-inflammatory properties of curcumin. The molecular targets and therapeutic uses of curcumin in health and disease","author":"Menon V. P.","year":"2007"},{"key":"e_1_2_13_220_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00026-9"},{"key":"e_1_2_13_221_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7911"},{"key":"e_1_2_13_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.12.016"},{"key":"e_1_2_13_223_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772312Y.0000000028"},{"key":"e_1_2_13_224_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059843"},{"key":"e_1_2_13_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.03.020"},{"key":"e_1_2_13_226_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-S1-S14"},{"key":"e_1_2_13_227_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135351"},{"key":"e_1_2_13_228_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1194"},{"key":"e_1_2_13_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.02.012"},{"key":"e_1_2_13_230_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0710-z"},{"key":"e_1_2_13_231_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-02704-1"},{"key":"e_1_2_13_232_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0702-x"},{"key":"e_1_2_13_233_2","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.5193-11.1"},{"key":"e_1_2_13_234_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2019.07.013"},{"key":"e_1_2_13_235_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5374.2013.36.004"},{"key":"e_1_2_13_236_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.11.050"},{"key":"e_1_2_13_237_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1768"},{"key":"e_1_2_13_238_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.12.055"},{"key":"e_1_2_13_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.07.040"},{"key":"e_1_2_13_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.11.002"},{"key":"e_1_2_13_241_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010049"},{"key":"e_1_2_13_242_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.08.004"},{"key":"e_1_2_13_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.07.056"},{"key":"e_1_2_13_244_2","doi-asserted-by":"publisher","DOI":"10.1179\/2045772313Y.0000000179"},{"key":"e_1_2_13_245_2","first-page":"439","article-title":"Mangiferin\u2013a bioactive xanthonoid, not only from mango and not just antioxidant","volume":"13","author":"Matkowski A.","year":"2013","journal-title":"Mini reviews in medicinal chemistry"},{"key":"e_1_2_13_246_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1299"},{"key":"e_1_2_13_247_2","first-page":"160","article-title":"Antiviral effect of mangiferin and isomangiferin on herpes simplex virus","volume":"103","author":"Zheng M.","year":"1990","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_13_248_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1292"},{"key":"e_1_2_13_249_2","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00009"},{"key":"e_1_2_13_250_2","doi-asserted-by":"publisher","DOI":"10.4155\/ppa-2016-0003"},{"key":"e_1_2_13_251_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.596"},{"key":"e_1_2_13_252_2","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110361752"},{"key":"e_1_2_13_253_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.165"},{"key":"e_1_2_13_254_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2016.01.011"},{"key":"e_1_2_13_255_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12160-6"},{"key":"e_1_2_13_256_2","doi-asserted-by":"publisher","DOI":"10.7507\/1002-1892.20160205"},{"key":"e_1_2_13_257_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102081-4.00004-6"},{"key":"e_1_2_13_258_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.1387"},{"key":"e_1_2_13_259_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.08.006"},{"key":"e_1_2_13_260_2","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2001)006<0044:EOSBPO>2.0.CO;2"},{"key":"e_1_2_13_261_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.047"},{"key":"e_1_2_13_262_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119214"},{"key":"e_1_2_13_263_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S137507"},{"key":"e_1_2_13_264_2","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0251"},{"key":"e_1_2_13_265_2","doi-asserted-by":"publisher","DOI":"10.4236\/pp.2015.68037"},{"key":"e_1_2_13_266_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6622"},{"key":"e_1_2_13_267_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4237973"},{"key":"e_1_2_13_268_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4090"},{"key":"e_1_2_13_269_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.526604"},{"key":"e_1_2_13_270_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27136"},{"key":"e_1_2_13_271_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.07.108"},{"key":"e_1_2_13_272_2","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2016_1272"},{"key":"e_1_2_13_273_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.082"},{"key":"e_1_2_13_274_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.12.007"},{"key":"e_1_2_13_275_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0083-8"},{"key":"e_1_2_13_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105077"},{"key":"e_1_2_13_277_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3738"},{"key":"e_1_2_13_278_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.03.037"},{"key":"e_1_2_13_279_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-91"},{"key":"e_1_2_13_280_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.07.037"},{"key":"e_1_2_13_281_2","doi-asserted-by":"publisher","DOI":"10.1179\/1743132811Y.0000000058"},{"key":"e_1_2_13_282_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.02.001"},{"key":"e_1_2_13_283_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2020.1773610"},{"key":"e_1_2_13_284_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.09.005"},{"key":"e_1_2_13_285_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.061"},{"key":"e_1_2_13_286_2","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2011.31391"},{"key":"e_1_2_13_287_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.oa.2013-0251"},{"key":"e_1_2_13_288_2","article-title":"Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy","volume":"1","author":"Li W.","year":"2021","journal-title":"The journal of spinal cord medicine"},{"key":"e_1_2_13_289_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23729"},{"key":"e_1_2_13_290_2","doi-asserted-by":"publisher","DOI":"10.3109\/10799893.2015.1049358"},{"key":"e_1_2_13_291_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7974"},{"key":"e_1_2_13_292_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.07.014"},{"key":"e_1_2_13_293_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00248"},{"key":"e_1_2_13_294_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000219"},{"key":"e_1_2_13_295_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7659"},{"key":"e_1_2_13_296_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg325"},{"key":"e_1_2_13_297_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.12.008"},{"key":"e_1_2_13_298_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20627"},{"key":"e_1_2_13_299_2","doi-asserted-by":"publisher","DOI":"10.1038\/417547a"},{"key":"e_1_2_13_300_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12964"},{"key":"e_1_2_13_301_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161207781368657"},{"key":"e_1_2_13_302_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678427"},{"key":"e_1_2_13_303_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-01-0016"},{"key":"e_1_2_13_304_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2008.07.004"},{"key":"e_1_2_13_305_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.01.004"},{"key":"e_1_2_13_306_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0039-x"},{"key":"e_1_2_13_307_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.02.002"},{"key":"e_1_2_13_308_2","first-page":"665","article-title":"Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2,-9, FAK, Rho A and ROCK-1 gene expression","volume":"23","author":"Lin H.-J.","year":"2010","journal-title":"Oncology reports"},{"key":"e_1_2_13_309_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.10.032"},{"key":"e_1_2_13_310_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.10.004"},{"key":"e_1_2_13_311_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0111"},{"key":"e_1_2_13_312_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.2.453"},{"key":"e_1_2_13_313_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1994.tb00981.x"},{"key":"e_1_2_13_314_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1426"},{"key":"e_1_2_13_315_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037574"},{"key":"e_1_2_13_316_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.012"},{"key":"e_1_2_13_317_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2114-11.2011"},{"key":"e_1_2_13_318_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0295"},{"key":"e_1_2_13_319_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.09.008"},{"key":"e_1_2_13_320_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1709-08.2008"},{"key":"e_1_2_13_321_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1998.00422.x"},{"key":"e_1_2_13_322_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.05.018"},{"key":"e_1_2_13_323_2","doi-asserted-by":"publisher","DOI":"10.21307\/ane-2018-035"},{"key":"e_1_2_13_324_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00671-x"},{"key":"e_1_2_13_325_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00690"},{"key":"e_1_2_13_326_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.202923"},{"key":"e_1_2_13_327_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29452"},{"key":"e_1_2_13_328_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22928"},{"key":"e_1_2_13_329_2","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"e_1_2_13_330_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182339"},{"key":"e_1_2_13_331_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.07.030"},{"key":"e_1_2_13_332_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59544-7.00014-7"},{"key":"e_1_2_13_333_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039500"},{"key":"e_1_2_13_334_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X663532"},{"key":"e_1_2_13_335_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.06.028"},{"key":"e_1_2_13_336_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1056"},{"key":"e_1_2_13_337_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2510-13.2013"},{"key":"e_1_2_13_338_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1483791"},{"key":"e_1_2_13_339_2","doi-asserted-by":"publisher","DOI":"10.1021\/nn405077y"},{"key":"e_1_2_13_340_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088916"},{"key":"e_1_2_13_341_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-01018-7"},{"key":"e_1_2_13_342_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2017.0203.003"},{"key":"e_1_2_13_343_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115966"},{"key":"e_1_2_13_344_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0564-z"},{"key":"e_1_2_13_345_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092"},{"key":"e_1_2_13_346_2","doi-asserted-by":"publisher","DOI":"10.4172\/2167-1206.1000133"},{"key":"e_1_2_13_347_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000352"},{"key":"e_1_2_13_348_2","first-page":"337","article-title":"Efficacy and safety of Meriva\u00ae, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients","volume":"15","author":"Belcaro G.","year":"2010","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_13_349_2","first-page":"105","article-title":"Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis","volume":"44","author":"Kertia N.","year":"2012","journal-title":"Acta Medica Indonesiana"},{"key":"e_1_2_13_350_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5174"},{"key":"e_1_2_13_351_2","first-page":"651","article-title":"Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation","volume":"24","author":"Satoskar R.","year":"1986","journal-title":"International journal of clinical pharmacology, therapy, and toxicology"},{"key":"e_1_2_13_352_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.081"},{"key":"e_1_2_13_353_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0425-2"},{"key":"e_1_2_13_354_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.01.007"},{"key":"e_1_2_13_355_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.02.014"},{"key":"e_1_2_13_356_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0779-0"},{"key":"e_1_2_13_357_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-017-1098-3"},{"key":"e_1_2_13_358_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.122937"},{"key":"e_1_2_13_359_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13076"},{"key":"e_1_2_13_360_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7719-2"},{"key":"e_1_2_13_361_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.08.050"},{"key":"e_1_2_13_362_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2005.05.011"},{"key":"e_1_2_13_363_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1879-6"},{"key":"e_1_2_13_364_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2019.105814"},{"key":"e_1_2_13_365_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.111716"},{"key":"e_1_2_13_366_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040913"},{"key":"e_1_2_13_367_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020434"},{"key":"e_1_2_13_368_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-019-03633-5"},{"key":"e_1_2_13_369_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100006X116664"},{"key":"e_1_2_13_370_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.05.037"},{"key":"e_1_2_13_371_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.019"},{"key":"e_1_2_13_372_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.09.033"},{"key":"e_1_2_13_373_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.174649"},{"key":"e_1_2_13_374_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx017"},{"key":"e_1_2_13_375_2","doi-asserted-by":"publisher","DOI":"10.1159\/000446647"},{"key":"e_1_2_13_376_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2020.02.004"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8100195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8100195.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/8100195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T23:52:16Z","timestamp":1748908336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/8100195"}},"subtitle":[],"editor":[{"given":"Dragan","family":"Hrn\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":376,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/8100195"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8100195","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8100195"}}