{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:51:09Z","timestamp":1747191069201,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:p>This study is aimed at reporting a rare and unusual focal choroidal excavation with a macular hole in a patient with Alagille syndrome (AGS). A 21-year-old woman with an established early-life AGS diagnosis was referred to our hospital prior to liver transplantation. Examination revealed best-corrected visual acuity of 16\/20 and 20\/20 in the right and left eye, respectively. Slit-lamp examination was positive for posterior embryotoxon in both eyes. Fundoscopy revealed diffuse choroidal hypopigmentation with increased visibility of the choroidal blood vessels and circumferential chorioretinal atrophy in the mid-peripheral and peripheral retina in both eyes. A full-thickness macular hole with underlying focal choroidal excavation was observed in the right eye. Optical coherence tomography through the macula confirmed choroidal excavation with a full-thickness macular hole in the right eye. To our knowledge, this is the first report describing focal choroidal excavation with a macular hole in an AGS patient.<\/jats:p>","DOI":"10.1155\/2022\/8136115","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T20:35:09Z","timestamp":1662410109000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Atypical Focal Choroidal Excavation with Macular Hole in a Patient with Alagille Syndrome"],"prefix":"10.1155","volume":"2022","author":[{"given":"Manami","family":"Misawa","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Jichi Medical University, Tochigi, Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Tampo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jichi Medical University, Tochigi, Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-3254","authenticated-orcid":true,"given":"Shinji","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jichi Medical University, Tochigi, Shimotsuke, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90072-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.7.27"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-021-09836-w"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000248819.86737.a5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316992"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000208"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_141_20"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2022\/8136115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2022\/8136115.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2022\/8136115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T20:35:11Z","timestamp":1662410111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criopm\/2022\/8136115\/"}},"subtitle":[],"editor":[{"given":"Cristiano","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":7,"alternative-id":["8136115","8136115"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8136115","relation":{},"ISSN":["2090-6730","2090-6722"],"issn-type":[{"type":"electronic","value":"2090-6730"},{"type":"print","value":"2090-6722"}],"subject":[],"published":{"date-parts":[[2022,9,5]]}}}