{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:53Z","timestamp":1772118533688,"version":"3.50.1"},"reference-count":131,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":108,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771237"],"award-info":[{"award-number":["81771237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801155"],"award-info":[{"award-number":["81801155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Noncoding RNAs (ncRNAs), such as microRNAs, long noncoding RNAs, and circular RNAs, play an important role in the pathophysiology of cerebrovascular diseases (CVDs). They are effectively detectable in body fluids, potentially suggesting new biomarkers for the early detection and prognosis of CVDs. In this review, the physiological functions of circulating ncRNAs and their potential role as diagnostic and prognostic markers in patients with cerebrovascular diseases are discussed, especially in acute ischemic stroke, subarachnoid hemorrhage, and moyamoya disease.<\/jats:p>","DOI":"10.1155\/2022\/8149701","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T18:35:13Z","timestamp":1650393313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Noncoding RNA as Diagnostic and Prognostic Biomarkers in Cerebrovascular Disease"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ruiyuan","family":"Weng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4580-2205","authenticated-orcid":false,"given":"Yuxiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30500-3"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2019.09.004"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6135-x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.050"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.688"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0206"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.147405"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071715-050711"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019055108"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr254"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300741"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3335"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2372"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1285"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq601"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu039"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/JNN.0b013e3181ce5c70"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2352040262"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091021"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000202524.43850.81"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201700007"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311572"},{"key":"e_1_2_9_25_2","first-page":"21071","article-title":"Elevated expressions of serum miR-15a, miR-16, and miR-17-5p are associated with acute ischemic stroke","volume":"8","author":"Wu J.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.12.019"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-178"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.03.007"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2020.1713540"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0659-2"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.156"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.00423"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3071-x"},{"key":"e_1_2_9_34_2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00057","article-title":"Increased circulating exosomal miRNA-223 is associated with acute ischemic stroke","volume":"8","author":"Chen Y.","year":"2017","journal-title":"Frontiers in Neurology"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.02.016"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.01.028"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-017-0104-9"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027348"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013869"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.09.009"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007482"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9842-1"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.055"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.05.036"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.05.002"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1975-0"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121288109"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.68"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058039"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.449025"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12142"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/350419"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.11.023"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.04.014"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep13316"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.064"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1145\/2818302"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24960"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9605-4"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091427"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15610786"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12589"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S121183"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2016.10.008"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.157"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.144576"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.12.021"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032662"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.157"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23255"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.113"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1310-6"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0155-9"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.09.072"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007041"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.898980"},{"key":"e_1_2_9_78_2","first-page":"3179","article-title":"Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke","volume":"8","author":"Liu W.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13697"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1159\/000447838"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017284"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx052"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26181"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.018"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00867-0"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70025-0"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.3.660"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.03.083"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182587839"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144724"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20160480"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180646"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00052.2015"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.1.JNS151454"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005363"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017804"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.09.008"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.07.028"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01745-0"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.03.007"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.11395"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2530-0"},{"key":"e_1_2_9_103_2","first-page":"2824","article-title":"LncRNA MEG3 participates in neuronal cell injury induced by subarachnoid hemorrhage via inhibiting the Pi3k\/Akt pathway","volume":"22","author":"Liang Z.","year":"2018","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-019-02886-2"},{"key":"e_1_2_9_105_2","article-title":"MiR-706 alleviates white matter injury via downregulating PKC\u03b1\/MST1\/NF-\u03baB pathway after subarachnoid hemorrhage in mice","volume":"341","author":"Ru X.","year":"2021","journal-title":"Experimental Neurology"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.07.051"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0155-8"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.FOCUS1150"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5424-8"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490714"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004386"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.245"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)00082-6"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102382"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10024"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.05.033"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.08.011"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.548278"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.282"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3001"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2957"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/532915"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.199505"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215566"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht007"},{"key":"e_1_2_9_127_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308434"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2015.48"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153200"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164644"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8149701.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8149701.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/8149701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:27:44Z","timestamp":1748914064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/8149701"}},"subtitle":[],"editor":[{"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/8149701"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8149701","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2021-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8149701"}}