{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:26:09Z","timestamp":1769153169846,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660812"],"award-info":[{"award-number":["81660812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,8,27]]},"abstract":"<jats:p>As a frequent disease affecting the nervous system, cerebral infarction has emerged as a major cause of disability and elicits disorders in motor, sensation, and cognition as sequelae. No clear mechanism has been known in meridian massage despite it having been proved to be an effective therapeutic option. The study was carried out to explore the treatment of meridian massage on cerebral ischemia in rats and its effects on motor function restoration and nerve cell\u2019s ultrastructure in the ischemic territory. The alleviated nerve damages and recovered injured brain tissues were found in the cerebral infarction model of SD rats after meridian massage. Expressions of miR-206 and the brain-derived neurotrophic factor (BDNF) in the gastrocnemius muscle were all well observed. The effects of miR-206 on BDNF were testified by overexpressed and interfered miR-206 in the C2C12 myoblast. Moreover, at the molecular level, meridian massage downregulated miR-206 expression at an elevated level of BDNF. Consequently, meridian massage exerts a vital role in promoting cerebral ischemia restoration, which is expected to provide an addition to the application of traditional Chinese medicine (TCM) in the reconstruction and treatment of cerebral ischemia.<\/jats:p>","DOI":"10.1155\/2022\/8172849","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T17:35:05Z","timestamp":1661621705000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["The Regulation of miR-206 on BDNF: A Motor Function Restoration Mechanism Research on Cerebral Ischemia Rats by Meridian Massage"],"prefix":"10.1155","volume":"2022","author":[{"given":"Guofeng","family":"Shi","sequence":"first","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinju","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhui","family":"Xie","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danguo","family":"Wen","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yan","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Gu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-5218","authenticated-orcid":true,"given":"Shuai","family":"Ma","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine, Guiyang 550000, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongwei","family":"Cai","sequence":"additional","affiliation":[{"name":"Southwest Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12883-020-1626-6","article-title":"Abnormal blood pressure circadian rhythms are relevant to cerebral infarction and Leukoaraiosis in hypertensive patients","volume":"20","author":"K. Yang","year":"2020","journal-title":"BMC Neurology"},{"key":"2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fneur.2020.00069","article-title":"Rapid recovery from cortical blindness caused by an old cerebral infarction","volume":"11","author":"K. Shibuki","year":"2020","journal-title":"Frontiers in Neurology"},{"key":"3","article-title":"Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation","volume":"242","author":"Z. Mo","year":"2020","journal-title":"Life Sciences"},{"issue":"4","key":"4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2174\/1570161112666141014150232","article-title":"Effects and perspectives of Chinese patent medicines for tonifying Qi and promoting blood circulation on patients with cerebral infarction","volume":"13","author":"L. Zhou","year":"2015","journal-title":"Current Vascular Pharmacology"},{"issue":"24","key":"5","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.12998\/wjcc.v8.i24.6282","article-title":"Effects of different acupuncture methods combined with routine rehabilitation on gait of stroke patients","volume":"8","author":"Y. T. Lou","year":"2020","journal-title":"World Journal of Clinical Cases"},{"key":"6","first-page":"2199","article-title":"Quantitative proteomic research of biological basis of Buyang Huanwu decoction therapy for cerebral infarction combined with Qi-deficiency and blood-stasis syndrome","volume":"43","author":"B. Ma","year":"2018","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-013-1137-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9946-7"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/01616412.2018.1524087","article-title":"Effect of regular swimming exercise to duration-intensity on neurocognitive function in cerebral infarction rat model","volume":"41","author":"M. K. Song","year":"2019","journal-title":"Neurological Research"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030644"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62395-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25051117"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.08.006"},{"issue":"1","key":"14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08474-0","article-title":"Inhibin-A and decorin secreted by human adult renal stem\/progenitor cells through the TLR2 engagement induce renal tubular cell regeneration","volume":"7","author":"F. Sallustio","year":"2017","journal-title":"Scientific Reports"},{"key":"15","first-page":"5729","article-title":"The bone marrow mononuclear cells reduce the oxidative stress of cerebral infarction through PI3K\/AKT\/NRF2 signaling pathway","volume":"21","author":"N. N. Chen","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.02.012"},{"issue":"2","key":"17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ana.23588","article-title":"miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model","volume":"72","author":"S. T. Lee","year":"2012","journal-title":"Annals of Neurology"},{"key":"18","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104540","article-title":"Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology","volume":"132","author":"S. D. Ginsberg","year":"2019","journal-title":"Neurobiology of Disease"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/00207454.2019.1667794","article-title":"Evaluation of the diagnostic value of peripheral BDNF levels for Alzheimer\u2019s disease and mild cognitive impairment: results of a meta-analysis","volume":"130","author":"B. Xie","year":"2020","journal-title":"International Journal of Neuroscience"},{"key":"20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neurobiolaging.2019.07.018","article-title":"Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons","volume":"84","author":"A. Shekari","year":"2019","journal-title":"Neurobiology of Aging"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010073"},{"issue":"39","key":"22","article-title":"Adjuvant laser meridian massage in men with opioid use disorder on methadone maintenance treatment: protocol for a case-controlled study","volume":"98","author":"W. L. Hu","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"25","key":"23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000020698","article-title":"Short and long-term efficacy of massage for functional constipation","volume":"99","author":"Y. Tang","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"24","first-page":"135","article-title":"The effects of abdominal meridian massage on constipation among CVA patients","volume":"35","author":"S. Y. Jeon","year":"2005","journal-title":"Taehan Kanho Hakhoe Chi"},{"issue":"2","key":"25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4040\/jkan.2013.43.2.247","article-title":"Effects of abdominal meridian massage with aroma oils on relief of constipation among hospitalized children with brain related disabilities","volume":"43","author":"M. J. Nam","year":"2013","journal-title":"Journal of Korean Academy of Nursing"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0316"},{"issue":"1","key":"27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1003-5257(15)30019-2","article-title":"Exceptional data in paper on the effect of meridian massage on BM, BMI, WC and HC in simple obesity patients: a randomized controlled tria","volume":"25","author":"D. M. Thomas","year":"2015","journal-title":"World Journal of Acupuncture-Moxibustion"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1900544116"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121578"},{"issue":"8","key":"30","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.4103\/1673-5374.189195","article-title":"miRNA targeted signaling pathway in the early stage of denervated fast and slow muscle atrophy","volume":"11","author":"G. Li","year":"2016","journal-title":"Neural Regeneration Research"},{"key":"31","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.12659\/MSM.897909","article-title":"MiR-206 attenuates denervation-induced skeletal muscle atrophy in rats through regulation of satellite cell differentiation via TGF-\u03b21, Smad3, and HDAC4 signaling","volume":"22","author":"Q. K. Huang","year":"2016","journal-title":"Medical Science Monitor"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1247\/csf.08022","article-title":"MicroRNA-206 is highly expressed in newly formed muscle fibers: implications regarding potential for muscle regeneration and maturation in muscular dystrophy","volume":"33","author":"K. Yuasa","year":"2008","journal-title":"Cell Structure and Function"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8172849.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8172849.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8172849.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T17:35:27Z","timestamp":1661621727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/8172849\/"}},"subtitle":[],"editor":[{"given":"Atul","family":"Kabra","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,27]]},"references-count":32,"alternative-id":["8172849","8172849"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8172849","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,27]]}}}