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Diabetes is a metabolic disease linked to multiple comorbidities, such as low-grade inflammation. \u03b2-pinene, a monoterpene commonly found in aromatic plants, is endowed with anti-inflammatory effect and this fact lead us to investigate the possible hypoglycemic, hypolipidemic and anti-inflammatory effects of the monoterpene in the alloxan-induced diabetes experimental model. Methods. Male Wistar rats (200\u2013250\u2009g) were treated orally with \u03b2-pinene (25, 50, 100, and 200\u2009mg\/kg) or glibenclamide (5\u2009mg\/kg), for seven consecutive days. Diabetes was induced by alloxan (40\u2009mg\/kg) through the penile vein. On the seventh day of treatment, blood samples were collected for biochemical analysis. The anti-inflammatory effect of \u03b2-pinene was evaluated using the carrageenan-induced paw edema model, followed by the carrageenan-induced peritonitis. Results. The treatment with \u03b2-pinene decreased plasma glucose, triglyceride, VLDL, LDL, and HDL levels, when compared to those of the control group. In addition, the association \u03b2-pinene 10\u2009mg\/kg\u2009+\u2009glibenclamide 2\u2009mg\/kg significantly decreased blood glucose, total cholesterol, and triglyceride level. Finally, oral treatment with \u03b2-pinene reduced carrageenan-induced paw edema and leukocyte migration in the peritoneum. Taken together, our results indicate that \u03b2-pinene shows hypoglycemic and hypolipemic effects, which may involve some common mechanisms of glibenclamide. Besides, the monoterpene presented an anti-inflammatory action in diabetic rats that needs further investigation in order to clarify such effect and its correlation with the alterations observed in plasma parameters of \u03b2-pinene-treated diabetic rats.<\/jats:p>","DOI":"10.1155\/2022\/8173307","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T23:05:14Z","timestamp":1652828714000},"page":"1-8","source":"Crossref","is-referenced-by-count":38,"title":["Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats"],"prefix":"10.1155","volume":"2022","author":[{"given":"Enaide Soares","family":"Santos","sequence":"first","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo Lucas","family":"Abrantes Coelho","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Kau\u00ea","family":"Saraiva Fontes Loula","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Louren\u00e7o","family":"Saraiva Landim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00edcera Norma","family":"Fernandes Lima","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Tavares de Sousa Machado","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Janice","family":"Pereira Lopes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acl\u00e9ssia Damiana","family":"Soares Gomes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Galberto","family":"Martins da Costa","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin Rose","family":"Alencar de Menezes","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":true,"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-156X","authenticated-orcid":true,"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00edcero Francisco","family":"Bezerra Felipe","sequence":"additional","affiliation":[{"name":"Federal University of Para\u00edba, UFPB, Jo\u00e3o Pessoa, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samya","family":"de Ara\u00fajo Neves","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Estacio of Juazeiro do Norte, FMJ, Juazeiro do Norte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Regina","family":"Kerntopf","sequence":"additional","affiliation":[{"name":"Regional University of Cariri, URCA, Crato, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"75","article-title":"Biochemical and Immunological interaction between diabetes mellitus and periodontal diseases in orthodontics","volume":"51","author":"F. 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