{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:35Z","timestamp":1787017775125,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2017XQ1184"],"award-info":[{"award-number":["2017XQ1184"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2018-1-98"],"award-info":[{"award-number":["2018-1-98"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2017XQ1184"],"award-info":[{"award-number":["2017XQ1184"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2018-1-98"],"award-info":[{"award-number":["2018-1-98"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2022,3,9]]},"abstract":"<jats:p>\n                    This study aims to investigate the risk factors associated with impaired pulmonary diffusing capacity among patients with noncystic fibrosis bronchiectasis (NCFB) and compare the predictive value of several scoring systems for the impairment in these patients. Between July 2019 and June 2021, patients who were admitted to the hospital and diagnosed with NCFB were included in this study. Clinical data were collected and analyzed retrospectively. A total of 175 NCFB patients were included in the analysis. Multivariate logistic regression analysis revealed that impaired pulmonary diffusing capacity diagnosed by carbon monoxide diffusing capacity (DLCO) &lt;80% prediction was associated with age, Reiff score, body mass index (BMI), comorbid chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Disease duration, frequency of exacerbation, hemoglobin level, and COPD were independent risk factors for impaired pulmonary diffusing capacity diagnosed by DLCO\/alveolar volume (VA) &lt;80% prediction. Age, Reiff score, and smoking status were independent risk factors for decreased VA diagnosed by VA &lt;80% prediction. The areas under the curve (AUC) for discrimination of DLCO &lt;80% prediction were 0.822 (0.760\u20130.885) for Bronchiectasis Severity Index (BSI), 0.787 (0.718\u20130.856) for FACED, 0.795 (0.729\u20130.863) for E-FACED, and 0.767 (0.694\u20130.839) for modified Medical Research Council (mMRC) scores; the AUC for discrimination of DLCO\/VA &lt;80% prediction was 0.803 (0.727\u20130.880) for BSI, 0.752 (0.669\u20130.835) for FACED, 0.757 (0.676\u20130.839) for E-FACED, and 0.762 (0.679\u20130.845) for mMRC, respectively. The BSI had the largest AUC, but the differences between those scoring systems had no statistical significance (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.181<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    for DLCO &lt;80% prediction and\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.105<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    for DLCO\/VA &lt;80% prediction). The mMRC score (up to 2 grades) showed a high specificity for discriminating diffusing dysfunction (88.3% for DLCO &lt;80% prediction and 76.1% for DLCO\/VA &lt;80% prediction). In NCFB patients, several factors such as age, Reiff score, BMI, exacerbation frequency, disease duration, and comorbid COPD and ILD were associated with impaired pulmonary diffusing capacity, which requires more attention in managing those patients. In addition, several scoring methods, including a simple index of mMRC, showed a comparable and moderate performance for predicting pulmonary diffusing impairment and would facilitate the systematic evaluation of the diffusing capacity of NCFB patients.\n                  <\/jats:p>","DOI":"10.1155\/2022\/8175508","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T17:05:07Z","timestamp":1646845507000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Risk Factors Associated with Impairment in Pulmonary Diffusing Capacity among Patients with Noncystic Fibrosis Bronchiectasis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-2186","authenticated-orcid":true,"given":"Kaijun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-188X","authenticated-orcid":true,"given":"Xin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-0007","authenticated-orcid":true,"given":"Zhiyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chencheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghang County Hospital, Longyan 364200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaosheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"222","article-title":"Recommendations for aetiological diagnosis of bronchiectasis","volume":"22","author":"Pulmonology Portuguese Society Bronchiectasis Study Group","year":"2016","journal-title":"Revista Portuguesa de Pneumologia"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01033-2015"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.04.007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2209"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.222.237"},{"issue":"5","key":"6","first-page":"379","article-title":"The prevalence and risk factors of bronchiectasis in residents aged 40 years old and above in seven cities in China","volume":"52","author":"Y. 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Sheng","year":"2016","journal-title":"International Journal of Respiration"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/8175508.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/8175508.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2022\/8175508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T17:05:16Z","timestamp":1646845516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crj\/2022\/8175508\/"}},"subtitle":[],"editor":[{"given":"Pierachille","family":"Santus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":22,"alternative-id":["8175508","8175508"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8175508","relation":{},"ISSN":["1916-7245","1198-2241"],"issn-type":[{"value":"1916-7245","type":"electronic"},{"value":"1198-2241","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}