{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:11:18Z","timestamp":1790881878704,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF2020R1I1A2066868"],"award-info":[{"award-number":["NRF2020R1I1A2066868"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    The increasing rates of antimicrobial resistance have demanded the development of new drugs as conventional antibiotics have become significantly less effective. Evidence has identified a variety of phytocompounds with the potential to be used in the combat of infections caused by multidrug\u2010resistant (MDR) bacteria. Considering the verification that terpenes are promising antibacterial compounds, the present research aimed to evaluate the antibacterial and antibiotic\u2010modulating activity of (+)\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pinene and (\u2010)\u2010borneol against MDR bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the compounds and antibiotics and further evaluate the intrinsic and associated antibiotic activity. These analyses revealed that (+)\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pinene showed significant antibacterial activity only against\n                    <jats:italic>E. coli<\/jats:italic>\n                    (MIC = 512\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g.mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), while no significant inhibition of\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    growth was observed (MIC \u2265 1024\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). However, when combined with antibiotics, this compound induced a significant improvement in the activity of conventional antibiotics, as observed for ciprofloxacin, amikacin, and gentamicin against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , as well as for amikacin and gentamicin against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , and amikacin against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    . On the other hand, (\u2010)\u2010borneol was found to inhibit the growth of\n                    <jats:italic>E. coli<\/jats:italic>\n                    and enhance the antibiotic activity of ciprofloxacin and gentamicin against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . The present findings indicate that (+)\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010pinene and (\u2010)\u2010borneol are phytocompounds with the potential to be used in the combat of antibacterial resistance.\n                  <\/jats:p>","DOI":"10.1155\/2022\/8217380","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T21:05:06Z","timestamp":1653512706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Potentiation of the Activity of Antibiotics against ATCC and MDR Bacterial Strains with (+)\u2010\n                    <i>\u03b1<\/i>\n                    \u2010Pinene and (\u2010)\u2010Borneol"],"prefix":"10.1155","volume":"2022","author":[{"given":"Nadghia F.","family":"Leite-Sampaio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicera N. F. 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C.","family":"Gondim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Ribeiro-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-4207","authenticated-orcid":false,"given":"Henrique D. M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_1_2","unstructured":"World Health Organization\u2013Who Antimicrobial resistance 2020."},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2018.351.3594"},{"key":"e_1_2_8_3_2","unstructured":"Disp\u00f5e sobre o controle de medicamentos \u00e0 base de subst\u00e2ncias classificadas como antimicrobianos de uso sob prescri\u00e7\u00e3o isoladas ou em associa\u00e7\u00e3o 2011 Anvisa. 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