{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:01:51Z","timestamp":1791594111702,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology Research International"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:p>Background. Chronic migraine, being a debilitating headache disorder, needs assessment of the risk factors implicated in its occurrence. We investigated the potential role of obesity as a risk for chronic migraine in premenopausal females with episodic migraine. Methods. In this analytical study, body fat% was compared between episodic and chronic migraine patient groups. The standard criteria of the international classification of headache disorder were used for the diagnosis. Demographic data, clinical details of migraine, and anthropometric measurements were collected using structured questions and standardized techniques. Pearson\u2019s correlation (r) was estimated to assess the concordance between body fat% and migraine frequency. High body fat%\u2019s implication on chronic migraine which was adjusted for body mass index (BMI), and the use of oral contraceptives was determined using logistic regression analysis. Results. A total of 168 premenopausal female migraineurs, with a mean (Standard deviation) age of 33.0 (\u00b19.0) years, were enrolled in the study. BMI and high body fat% were significantly associated with chronic migraine (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mtext>0<\/a:mtext>\n                        <a:mn>.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). There was a weak positive, but significant, correlation between body fat% and migraine frequency (r\u2009=\u20090.185, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mtext>0<\/c:mtext>\n                        <c:mn>.017<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The presence of high body fat was found to increase the risk of chronic migraine by 2.8 times (confidence interval 1.4\u20135.6; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mtext>0<\/e:mtext>\n                        <e:mn>.003<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Conclusion. The amount of fat mass in the body relates to the clinical characteristics of migraine. There is an increased risk of developing chronic migraine in patients having high body fat. Weight control measures can be targeted for the prevention of migraine worsening.<\/jats:p>","DOI":"10.1155\/2022\/8219254","type":"journal-article","created":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T20:35:08Z","timestamp":1665866108000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["Implication of High Body Fat Percentage on Migraine Chronification in Premenopausal Females"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-1555","authenticated-orcid":true,"given":"Pooja","family":"Ojha","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Era\u2019s Lucknow Medical College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0616-y"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-003-0033-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-010-0165-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-016-0540-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.32"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0470-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0895-6"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.04.004"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2012.05684.x"},{"issue":"6","key":"10","first-page":"403","article-title":"Comparison of the effectiveness of body mass index and body fat percentage in defining body composition","volume":"53","author":"A. R. Goonasegaran","year":"2012","journal-title":"Singapore Medical Journal"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000197218.05284.82"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01554.x"},{"issue":"1","key":"13","first-page":"23","article-title":"The effect of body fat mass and fat free mass on migraine headache","volume":"12","author":"S. R. Jahromi","year":"2013","journal-title":"Iran Journal of Neurology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/head.12763"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1079\/bjn19740060"},{"key":"17","article-title":"Body composition from fluid spaces and density: analysis of methods","volume-title":"Techniques for Measuring Body Composition","author":"W. E. Siri","year":"1961"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01163-w"},{"issue":"2","key":"19","first-page":"55","article-title":"Hormonal contraceptive options for women with headache: a review of the evidence","volume":"3","author":"A. G. Edlow","year":"2010","journal-title":"Reviews in Obstetrics and Gynecology"},{"key":"20","first-page":"163","article-title":"Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management","volume":"57","author":"A. Misra","year":"2009","journal-title":"Journal of the Association of Physicians of India"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01459.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0510-z"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2013.28.4.6504"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01360.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.761"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011843"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01706.x"}],"container-title":["Neurology Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2022\/8219254.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2022\/8219254.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/nri\/2022\/8219254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T20:35:19Z","timestamp":1665866119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/nri\/2022\/8219254\/"}},"subtitle":[],"editor":[{"given":"Pragney","family":"Deme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,15]]},"references-count":27,"alternative-id":["8219254","8219254"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8219254","relation":{},"ISSN":["2090-1860","2090-1852"],"issn-type":[{"value":"2090-1860","type":"electronic"},{"value":"2090-1852","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,15]]}}}