{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:52:30Z","timestamp":1747191150013,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,26]]},"abstract":"<jats:p>Objective. To explore the efficacy of intravenous thrombolysis combined with arterial thrombolysis (bridging therapy) in patients with acute cerebral infarction and its effect on serum inflammatory factors. Methods. The case data of 138 patients with acute cerebral infarction admitted to our hospital from February 2019 to February 2021 were retrospectively analyzed. According to the treatment plan they received, patients were assigned to two groups, namely, an observation group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>71<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) treated with bridging therapy and a control group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>67<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) treated with intravenous thrombolysis alone. The following indexes were recorded and compared between the two groups: treatment efficacy, National Institutes of Health Stroke Scale (NIHSS) score, activities of daily living, incidence rates of vascular recanalization, intracranial hemorrhage and reembolization after treatment, levels of inflammatory factors before and after treatment, levels of prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) before and 1 week after treatment, and modified Rankin Scale scores 1, 3, and 6 months after treatment. Results. Compared with the control group, the therapeutic efficacy, neurological function, activities of daily living, and vascular recanalization were markedly better in the observation group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). In addition, the incidence of intracranial hemorrhage and reembolization was statistically lower in the observation group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). No marked difference was found between the two groups in terms of pretreatment serum inflammatory factors and coagulation function (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), while the above indicators improved statistically after treatment in both groups, with comparatively more obvious improvement in the observation group. It was also observed that, compared with the control group, the modified Rankin Scale score in the observation group was significantly better at 3 and 6 months after treatment (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. Bridging therapy can improve the vascular recanalization rate among patients suffering from acute cerebral infarction, reduce the incidence of intracranial hemorrhage and reembolization, and improve the prognosis and neurological function of patients, which is worthy of clinical application.<\/jats:p>","DOI":"10.1155\/2022\/8295212","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T16:36:03Z","timestamp":1658853363000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Intravenous Thrombolysis Combined with Arterial Thrombolysis (Bridging Therapy) Effectively Improves Vascular Recanalization Rate in Patients with Cerebral Infarction"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2193-7404","authenticated-orcid":true,"given":"Junting","family":"Huo","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Chuiyangliu Hospital, Beijing 100022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Chuiyangliu Hospital, Beijing 100022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Chuiyangliu Hospital, Beijing 100022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010103"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10622-6"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8864756"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6620311"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1673-4254.2021.09.20"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2833043"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000446105.67173.a8"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-011-0317-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.08.196"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.17992\/lbl.2014.0708.553"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12477"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-019-01306-1"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017866"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012642"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.04.024"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-007-0003-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92041-1"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2020.01.352"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1177\/1591019919886405"},{"issue":"17","key":"20","first-page":"5740","article-title":"Clinical treatment efficiency of mechanical thrombectomy combined with rh pro-UK thrombolysis for acute moderate\/severe cerebral infarction","volume":"22","author":"Q. 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