{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:50:53Z","timestamp":1793256653809,"version":"4.5.0"},"reference-count":101,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurology Research International"],"published-print":{"date-parts":[[2022,10,12]]},"abstract":"<jats:p>Aim. Neuropathic pain affects 7\u201310% of the population, with most of the patients receiving inadequate and incomplete treatment. Owing to the high financial burden and the poor quality of life of the patients and their caretakers, there is a dire need to address the challenges in diagnosing and treating chronic neuropathic pain. Methods. This literature review was conducted to review novel treatments and related challenges through a systematic search from sources such as PubMed, Google Scholar with the combination of MESH words such as neuropathic pain, management of neuropathic pain. Articles from non-English literature, reports without human subjects, animal studies, and abstracts\/posters were excluded. However, human studies and studies published in English were included. Result. This review article discusses novel treatment modalities while acknowledging the challenges medical workers face while encountering neuropathic pain. Despite the recent advances in diagnosis and treatment modalities, several challenges still exist. Hence, there is still a need to explore the various treatment modalities, emphasizing the cause and underlying pathophysiology of neuropathic pain. Conclusion. We recommend integrated multimodal treatment with the current treatment facility, including various medical disciplines. However, a personalized approach would work the best depending on the \u2019patient\u2019s medical history. Therefore, this article recommends an integrated, cause-specific, cost-effective approach to address this problem of chronic neuropathic pain.<\/jats:p>","DOI":"10.1155\/2022\/8336561","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T20:05:22Z","timestamp":1665605122000},"page":"1-14","source":"Crossref","is-referenced-by-count":46,"title":["Managing Chronic Neuropathic Pain: Recent Advances and New Challenges"],"prefix":"10.1155","volume":"2022","author":[{"given":"Namrata","family":"Hange","sequence":"first","affiliation":[{"name":"National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-2095","authenticated-orcid":true,"given":"Sujan","family":"Poudel","sequence":"additional","affiliation":[{"name":"National Medical College, Tribhuvan University, Birgunj, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha","family":"Ozair","sequence":"additional","affiliation":[{"name":"Department of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trissa","family":"Paul","sequence":"additional","affiliation":[{"name":"Larkin Community Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Nambakkam","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakchhya","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ascension St. Agnes Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Greye","sequence":"additional","affiliation":[{"name":"Department of Research & Academic Affairs, Larkin Community Hospital, South Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-3329","authenticated-orcid":true,"given":"Sangam","family":"Shah","sequence":"additional","affiliation":[{"name":"Tribhuvan University, Institute of Medicine, Maharajgunj, Kirtipur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagya","family":"Raj Adhikari","sequence":"additional","affiliation":[{"name":"Tribhuvan University, Institute of Medicine, Maharajgunj, Kirtipur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangharsha","family":"Thapa","sequence":"additional","affiliation":[{"name":"University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Larkin Community Hospital, South Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PAIN.2013.11.013"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2017.2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171109132650"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4065\/MCP.2009.0649"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200927020-00002"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.2\/DIONESCU"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8685954"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0B013E328363B4BF"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/J.MAYOCP.2015.01.018"},{"key":"11","first-page":"3","article-title":"Diagnosis and management of neuropathic pain: a balanced approach to treatment","volume":"15","author":"B. 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