{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:40:07Z","timestamp":1740156007777,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8196030872","47"],"award-info":[{"award-number":["8196030872","47"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zunyi Science and Technology Project","award":["8196030872","47"],"award-info":[{"award-number":["8196030872","47"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,6,8]]},"abstract":"<jats:p>Background. Corneal collagen cross-linking (CXL) therapy, a method that uses a combination of riboflavin and ultraviolet-A light (UVA), can promote the formation of covalent cross-linking of amino acid residues of corneal collagen and enhance the hardness of the cornea. In this study, we explored the effects of corneal stromal lens collagen cross-linking regraft on corneal biomechanics. Methods. A total of 15 New Zealand white rabbits were divided into 3 groups: normal control group (group A), SMILE\u2009+\u2009uncross-linked lens implantation group (Group B), and SMILE\u2009+\u2009cross-linking lens implantation group (group C). The design parameters of SMILE surgery were as follows: the corneal cap was 120 um thick, the lens diameter was 6.5\u2009mm, and the diopter was -6.0D. Riboflavin and ultraviolet-A (UVA) were used as corneal stromal lens CXL, which was implanted into the allogeneic rabbit corneal stromal bag 24 hours after the operation. Postoperative corneal thickness (CCT), refraction, AS-OCT, and corneal biomechanics were performed before and then at 1 and 3 months after the operation. Results. All corneas appeared transparent and smooth 3 months after surgery. The corneal thicknesses of both group B and group C were lower than those before the operation. The corrected refraction of group B and group C after lens implantation was also lower than the expected corrected power; there was no significant difference between the two groups (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). AS-OCT results showed an uneven surface and thickness of the corneal stromal lens in two eyes of group B. Moreover, corneal elastic deformation increased with intraocular pressure in each group; displacement from large to small was group B\u2009&gt;\u2009group C and\u2009&gt;\u2009group A. The creep from large to small was group B\u2009&gt;\u2009group C\u2009&gt;\u2009group A. The fiberboard layers of groups B and C were disordered, and there were a few autophagosomes in the fibroblasts of group B by transmission electron microscopy (TEM). Conclusions. Allograft graft of corneal stromal lens collagen cross-linked can significantly increase the biomechanical properties of the cornea.<\/jats:p>","DOI":"10.1155\/2022\/8372156","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T06:50:29Z","timestamp":1654757429000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Corneal Stromal Lens Collagen Cross-Linking Regraft on Corneal Biomechanics"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-4271","authenticated-orcid":true,"given":"Rong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Myopia and Cataract Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weize","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Myopia and Cataract Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Myopia and Cataract Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaorong","family":"Linghu","sequence":"additional","affiliation":[{"name":"Department of Myopia and Cataract Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0573-8349","authenticated-orcid":true,"given":"Taixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Myopia and Cataract Center, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 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