{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:24:34Z","timestamp":1791930274717,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":230,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This study aims to explore the application value of the <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT imaging in diagnosing, staging, and typing Langerhans cell histiocytosis (LCH) via the morphological and metabolic analyses of the <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT images. <jats:italic>Methods<\/jats:italic>. We retrospectively analyzed the <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT images and clinical data of nineteen patients with LCH. The shape, size, density, distribution, and <jats:sup>18<\/jats:sup>F\u2010FDG uptake of all lesions were documented. In addition, the SUVmax of the lesions, liver, and blood pool was measured prior to calculating the lesion\u2010to\u2010liver and lesion\u2010to\u2010blood pool ratios. <jats:italic>Results<\/jats:italic>. Among the 19 analyzed patients, the positive rate of the PET\/CT image was 94.7% (18\/19), with 1 false negative (5.3%, 1\/19) case occurring in the cutaneous LCH. Among the 76 lesions, 69 were FDG\u2010avid lesions (69\/76, 90.8%). Additionally, we observed no FDG uptake in 7 lesions (7\/76, 9.2%). In contrast, 59 lesions (59\/76, 77.6%) were abnormal on diagnostic CT scan, but 17 lesions (17\/76, 22.4%) were undetected. The <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT image revealed additional 6 lesions in the bone, 4 in the lymph node, 3 in the spleen, and 3 occult lesions, which CT scan did not detect. Additionally, there were 6 cases with single\u2010system LCH. The remaining 13 cases were multisystem LCH. Our <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT image analyses altered the typing of 4 LCH patients. In the case of all lesions, the mean SUVmax of the <jats:sup>18<\/jats:sup>F\u2010FDG\u2010avid lesions was 5.4\u2009\u00b1\u20095.1 (range, 0.8\u223c26.2), and the mean lesion\u2010to\u2010liver SUVmax ratio was 3.1\u2009\u00b1\u20092.52 (range, 0.7\u223c11.9), and the mean lesion\u2010to\u2010blood pool SUVmax ratio was 4.6\u2009\u00b1\u20093.4 (range 0.7\u223c17.5). <jats:italic>Conclusion<\/jats:italic>. The <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT image plays an essential role in LCH diagnosis, primary staging, and typing. It can accurately evaluate the distribution, range, and metabolic information of LCH, providing a vital imaging basis for the clinical evaluation of disease conditions, selection of treatment schemes, and determining patient prognosis.<\/jats:p>","DOI":"10.1155\/2022\/8385332","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T23:20:07Z","timestamp":1660951207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Application of <sup>18<\/sup>F\u2010FDG PET\/CT in Langerhans Cell Histiocytosis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Fengxiang","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehuang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanling","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinggui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-6150","authenticated-orcid":false,"given":"Bing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.02.023"},{"key":"e_1_2_13_2_2","first-page":"122","article-title":"Langerhans cell histiocytosis: emerging insights and clinical implications","volume":"30","author":"Zinn D. 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