{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:25:47Z","timestamp":1758705947016,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":93,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Comparing the outcomes of debridement and total hip arthroplasty (THA) with antibiotic\u2010loaded spacer implantation and subsequent THA for the treatment of patients affected by primary advanced septic arthritis (SA) of the hip in adults. <jats:italic>Methods<\/jats:italic>. All of the 20 patients (20 hips) underwent two\u2010stage surgery. Nine patients were submitted to surgical debridement first and then THA (group 1), while 11 patients were treated with antibiotic\u2010loaded spacer and subsequent THA (group 2). Patients were evaluated based on the recurrence of infection, Harris hip score, visual analogue scale (VAS) pain score, and leg length discrepancy. <jats:italic>Results<\/jats:italic>. No cases of infection, deep vein thrombosis, death, and loosening of the hip prosthesis were observed during follow\u2010up. The mean follow\u2010up time was 29.09 \u00b1 10.80 months in group 1 and 28.22 \u00b1 14.80 months in group 2. Before the THA surgery, the mean leg length discrepancy was 2.80 \u00b1 2.03\u2009cm in group 1 and 0.50 \u00b1 0.23\u2009cm in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05). In the latest follow\u2010up, the Harris hip scores of patients were 90.33 \u00b1 4.85 in group 1 and 94.36 \u00b1 2.34 in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05), respectively. There was no statistically significant difference in the VAS pain score of the hip between the two groups (<jats:italic>P<\/jats:italic> &gt; 0.05). <jats:italic>Conclusions<\/jats:italic>. Debridement and antibiotic\u2010loaded spacer and subsequent THA were effective in eradicating the infection for advanced SA. However, antibiotic\u2010loaded spacer and subsequent THA was superior for effectively maintaining the length of the lower limb and function of the hip.<\/jats:p>","DOI":"10.1155\/2022\/8387465","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T02:05:05Z","timestamp":1649124305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Two\u2010Stage Total Hip Arthroplasty for Primary Advanced Septic Arthritis of the Hip in Adults"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-1205","authenticated-orcid":false,"given":"Zhenzhong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-6167","authenticated-orcid":false,"given":"Congcong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-4470","authenticated-orcid":false,"given":"Xiangke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-8814","authenticated-orcid":false,"given":"Mengxuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4797-8631","authenticated-orcid":false,"given":"Huijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmm.IJMM_19_134"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.13.1478"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198309000-00008"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016765"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.181621"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1074-4"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0082-6"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800059070"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0364-3"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.02.001"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61595-6"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1754-9493-3-6"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197052080-00007"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8713037"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-007-0366-1"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6.234"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09522-6"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2018.10.40974"},{"key":"e_1_2_12_19_2","first-page":"869","article-title":"Diagnosis of periprosthetic infection","volume":"88","author":"Bauer T. 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