{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:37:57Z","timestamp":1780105077255,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["23264"],"award-info":[{"award-number":["23264"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2022,7,7]]},"abstract":"<jats:p>Despite the recommendation for early diagnosis and rapid initiation of HIV treatment, more than half of patients are in an advanced stage of HIV disease in Iran. This study aimed to investigate the factors related to baseline CD4 cell count and advanced HIV disease (AHD) in Southern Iran. The study comprised all adults between 15 and 87 years of age who were newly diagnosed with HIV in Southern Iran. Linear and logistic regressions were used to identify baseline CD4 cell count predictors and AHD, respectively. A total of 820 (53.9%) HIV-infected individuals over 15 years of age were at the AHD stage. Based on the results of the multiple logistic regression, older age at diagnosis (OR\u226540\/&lt;30\u2009=\u20092.68, 95% CI\u2009=\u20091.38\u20135.19), gender (ORfemale\/male\u2009=\u20090.62, 95% CI\u2009=\u20090.44\u20130.85), HIV\/TB coinfection (ORyes\/no\u2009=\u20091.98, 95% CI\u2009=\u20091.29\u20133.02), HIV\/HBV coinfection (ORyes\/no\u2009=\u20091.58, 95% CI\u2009=\u20091.07\u20132.38), and hemoglobin (OR\u2009=\u20090.89, 95% CI\u2009=\u20090.85\u20130.92) were directly associated with AHD in HIV\/AIDS patients. As suggested by a linear regression model, factors including gender (B Female\u2009=\u200944.12, 95% CI:17.86, 70.38), older age (B\u2009\u2265\u200940\u2009=\u2009\u2212111.99, 95% CI:\u2212174.70, \u221249.27), higher education level (B\u2009=\u200935.65, 95% CI:5.34, 65.97), WHO clinical stage (BIV\u2009=\u2009\u2212254.53, 95% CI\u2212298.82, \u2212210.24), and hemoglobin (B\u2009=\u20095.23, 95% CI:0.25, 10.20) were significantly associated with CD4 count.The prevalence of AHD in patients was high in Iran. Our results suggested that several demographic and clinical factors are significantly associated with the baseline CD4 cell count and AHD. Targeted HIV testing, implementation of screening programs for early detection, and access to care services to assure early ART are recommended to improve the clinical status and quality of life of the patients.<\/jats:p>","DOI":"10.1155\/2022\/8423347","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T21:20:07Z","timestamp":1657228807000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Factors Associated with Baseline CD4 Cell Counts and Advanced HIV Disease among Male and Female HIV-Positive Patients in Iran: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-2084","authenticated-orcid":true,"given":"Sima","family":"Afrashteh","sequence":"first","affiliation":[{"name":"Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-328X","authenticated-orcid":true,"given":"Mohammad","family":"Fararouei","sequence":"additional","affiliation":[{"name":"HIV\/AIDs Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-392X","authenticated-orcid":true,"given":"Haleh","family":"Ghaem","sequence":"additional","affiliation":[{"name":"Non-Communicable Diseases Research Center, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-6815","authenticated-orcid":true,"given":"Mohammad","family":"Aryaie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"HIV\/AIDS","author":"WHO","year":"2021"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000002757"},{"key":"3","volume-title":"HIV and AIDS Estimates in the Islamic Republic of Iran","author":"UNAIDS","year":"2020"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000002063"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164148"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017871"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-021-05523-w"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242278"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230205"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1139"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-3826-5"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2019.1679472"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226987"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2021.1975629"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1590\/s1413-86702005000600004"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2147\/hiv.s273649"},{"issue":"2","key":"17","first-page":"65","article-title":"Correlation of WHO clinical staging with CD4 counts in adult HIV\/AIDS patients at Kenyatta National Hospital, Nairobi","volume":"88","author":"C. S. Ilovi","year":"2011","journal-title":"East African Medical Journal"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/2325958219847199"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096098"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25642"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06100-z"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2012.3585"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5852-4"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73852-0"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.4103\/ijstd.ijstd_11_17"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2016.02.589"},{"issue":"3","key":"27","first-page":"138","article-title":"Correlation of CD4 lymphocyte count with hemoglobin concentration in HIV infected patients at HIV Treatment Center PIMS Islamabad","volume":"9","author":"R. A. Qazi","year":"2013","journal-title":"Annals of Pakistan Institute of Medical Sciences"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-102"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.08.001"}],"container-title":["Journal of Tropical Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2022\/8423347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2022\/8423347.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2022\/8423347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T21:20:14Z","timestamp":1657228814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jtm\/2022\/8423347\/"}},"subtitle":[],"editor":[{"given":"Wenping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":29,"alternative-id":["8423347","8423347"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8423347","relation":{},"ISSN":["1687-9694","1687-9686"],"issn-type":[{"value":"1687-9694","type":"electronic"},{"value":"1687-9686","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,7]]}}}