{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:51:00Z","timestamp":1747191060988,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:p>Introduction. Stillbirth has been documented as an outcome of SARS-CoV-2 infection in pregnancy. Placental hypoperfusion and inflammation secondary to maternal immune response seem to play a role in the cascade of events that contribute to fetal death. The aim of our study is to report a perinatal outcome of SARS-CoV-2 infection in pregnancy adding information to the pool of data on COVID-19 pregnancy outcomes. Case Presentation. This is the first stillbirth case series occurring in pregnant women infected with SARS-CoV-2 in a Portuguese cohort. Between April 2020 and March 2021, we had 2680 births in our centre, of which 130 (4.95%) involved mothers infected with SARS-CoV-2. Of total births, there were 14 stillbirths (0.52%), accounting for the highest stillbirth rate we have had in the last 5 years. Among these 14 stillbirths, 5 (35.71%) occurred in SARS-CoV-2-infected mothers. We report the clinical features and placental histopathologic findings of 4 stillbirth cases that occurred in our hospital. Discussion. The stillbirth rate among SARS-CoV-2-infected pregnant women (5\/130; 3.84%) was significantly increased compared to noninfected patients (9\/2550; 0.35%). Most women (3\/4) were asymptomatic for COVID-19, a surprising outcome, given the current literature. All cases had histologic exams showing placental signs of vascular malperfusion, although we acknowledge that 3\/5 had obstetric conditions related to placental vascular impairment such as preeclampsia and HELLP syndrome. Conclusion. Stillbirth can be a perinatal consequence of SARS-CoV-2 infection in pregnancy, even in asymptomatic patients. We urge more studies to explore the association between SARS-CoV-2 infection and the risk of stillbirth.<\/jats:p>","DOI":"10.1155\/2022\/8423733","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T20:20:07Z","timestamp":1659558007000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Fetal Deaths in SARS-CoV-2-Infected Pregnant Women: A Portuguese Case Series"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-1607","authenticated-orcid":true,"given":"Ana Rita","family":"Mira","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-3824","authenticated-orcid":true,"given":"Jo\u00e3o Pedro","family":"Pereira","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-0876","authenticated-orcid":true,"given":"Catrine","family":"Dahlstedt-Ferreira","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-6042","authenticated-orcid":true,"given":"Margarida","family":"Enes","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5342-8081","authenticated-orcid":true,"given":"H\u00e9lder Oliveira","family":"Coelho","sequence":"additional","affiliation":[{"name":"Pathology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-845X","authenticated-orcid":true,"given":"Ana Beatriz","family":"Godinho","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"author":"W. 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