{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:08:54Z","timestamp":1773745734703,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CERNET Innovation","award":["NGII20190706"],"award-info":[{"award-number":["NGII20190706"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>As a common cardiovascular disease, acute myocardial infarction seriously affects the health and life of patients. miRNAs play an important role in acute myocardial infarction. Based on miRNA obtained from the previous sequencing, this study investigated whether miRNA (miR)\u2010124\u20103p\u2010loaded nanoparticles (NPs) affect the phenotype of the acute myocardial infarction (AMI) rat. Nano\u2010miR\u2010124\u20103p decreased the myocardial infarction area, improved the myocardial tissue structure, and increased the degree of fibrosis. Nano\u2010miR\u2010124\u20103p decreased apoptosis and the expression of cleaved caspase 3, indicating its role in protecting and repairing the myocardium. To further verify the action mechanism of miRNA, a potential target gene of miR\u2010124\u20103p, PTEN was identified by STARBASE and further confirmed using double luciferase assays. Following cotransfection of nano\u2010miR\u2010124\u20103p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated. The expression of cleaved caspase 3 and the apoptosis rate in the nano\u2010miR\u2010124\u20103p and PTEN cotransfection group was also significantly increased. Bioinformatics analysis revealed that miRNA\u2010124\u20103 may regulate oxidative stress injury by targeting PTEN. Taken together, miR\u2010124\u20103p could protect and repair myocardial tissues through targeting PTEN.<\/jats:p>","DOI":"10.1155\/2022\/8428596","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T23:06:12Z","timestamp":1665529572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["[Retracted] Activation of PTEN\/P13K\/AKT Signaling Pathway by miRNA\u2010124\u20103p\u2010Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yuan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-4609","authenticated-orcid":false,"given":"Qing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1725769"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.143"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-16-1-16"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/15132.6684"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2019.12.012"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6345284"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x202010550"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5742608"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-021-00822-z"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1586\/erm.09.15"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1815896"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.10.014"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110294"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8010013"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM01206C"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020243"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.09.063"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004464"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2019-136409"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1907"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2007"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.02.021"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2018_064"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06347-4"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10565"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1717041"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165768"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.024"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43895"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1179\/1351000215Y.0000000011"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28723"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.10.014"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2017.1343118"}],"updated-by":[{"DOI":"10.1155\/2023\/9768785","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"record-id":"57845"},{"DOI":"10.1155\/2023\/9768785","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000}}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8428596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/8428596.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/8428596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:11:54Z","timestamp":1748913114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/8428596"}},"subtitle":[],"editor":[{"given":"Md Sayed","family":"Ali Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/8428596"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8428596","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9768785","asserted-by":"object"}]},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8428596"}}