{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:09:51Z","timestamp":1769548191279,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2020M683128"],"award-info":[{"award-number":["2020M683128"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["82100648"],"award-info":[{"award-number":["82100648"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["81870404"],"award-info":[{"award-number":["81870404"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020M683128"],"award-info":[{"award-number":["2020M683128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100648"],"award-info":[{"award-number":["82100648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870404"],"award-info":[{"award-number":["81870404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:p>Aim. Associations between antinuclear antibodies (ANAs) and disease severity in nonalcoholic fatty liver disease (NAFLD) remain unclear. This study aimed to provide reliable estimates of ANA prevalence in subjects with biopsy-proven NAFLD and to investigate whether its associations with liver disease severity were established. Methods. Observational studies measuring ANA in NAFLD patients were derived from the PubMed, Embase, and Web of Science databases from inception to March 30, 2022. The effect size was presented as the pooled risk difference, unstandardized mean differences (MDs), and odds ratio (OR) with a 95% confidence interval (CI). Results. Thirteen articles involving 2331 patients were finally included. Among the subjects with biopsy-proven NAFLD, the overall prevalence of ANA positivity was high as 23% (95% CI: 19%-28%), but there were no statistically significant differences between ANA-positive and ANA-negative NAFLD patients in the levels of liver enzymes and blood lipids, grades of hepatocellular ballooning, lobular and portal inflammation, or risks of moderate-severe steatosis and significant fibrosis. However, the subgroup analysis showed that different geographic regions led to diverse results. ANA positivity was associated with a significantly elevated risk of significant fibrosis in the Eastern population (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>OR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>2.30<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 1.30-4.06) but not in the Western population (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>OR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.00<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% CI: 0.54-1.83). Conclusions. Serum ANA was present in approximately one-quarter of subjects with biopsy-proven NAFLD, but it conferred a greater risk of significant fibrosis only in Eastern but not Western populations.<\/jats:p>","DOI":"10.1155\/2022\/8446170","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T16:06:30Z","timestamp":1660320390000},"page":"1-12","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Significance of Antinuclear Antibodies in Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ling","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"},{"name":"Department of Infectious Diseases, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3163-4164","authenticated-orcid":true,"given":"Junzhao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-7699","authenticated-orcid":true,"given":"Bihui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology of the First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10094-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.584396"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20223"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00609"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000004522.36120.08"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30294-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30213-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30340-X"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12696"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000139072.38580.a0"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000676"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.10.004"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.4.2.185-188"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.032"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01377.x"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"22","first-page":"1","article-title":"Celiac disease. 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