{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:39Z","timestamp":1740140319164,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP-2021\/132"],"award-info":[{"award-number":["RSP-2021\/132"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>The goal of the current study was to assess the nephroprotective and cardioprotective potential of Moricandia sinaica methanol extract (MOR-1), as well as its butanol (MOR-2) and aqueous (MOR-3) fractions against carbon tetrachloride (CCl4)-induced nephro and cardio-toxicity. Cardiac function was assessed using the biochemical parameters lactate dehydrogenase (LDH) and creatinine kinase (CK). Renal function was examined using the biochemical parameters creatinine and uric acid. The levels of nonprotein sulfhydryls (NPSH) and malondialdehyde (MDA) were used as markers of oxidative strain. A dose of 100 and 200\u2009mg\/kg of butanol fraction given prior to CCl4 treatment significantly (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                        <a:mo>\u2212<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) protected against elevated LDH and CK levels. Similarly, treatment with silymarin (10\u2009mg\/kg) and butanol fraction (100 and 200\u2009mg\/kg) significantly (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                        <c:mo>\u2212<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) boosted total protein levels compared to CCl4 treatment alone. The silymarin (10\u2009mg\/kg) and butanol fraction (100 and 200\u2009mg\/kg) also provided a significant (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                        <e:mo>\u2212<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) protective effect for MDA levels. Methanol extract (MOR-1) and butanol (MOR-2) showed significant results and were recommended for further pharmacological and screening for active constituents.<\/jats:p>","DOI":"10.1155\/2022\/8545695","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T20:05:17Z","timestamp":1656533117000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-3196","authenticated-orcid":true,"given":"Abdelaaty A.","family":"Shahat","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Chemistry of Medicinal Plants Department, National Research Centre, 33 El Bohouth St. (Former El Tahrirst.), Dokki, P.O. 12622, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba D.","family":"Hassanein","sequence":"additional","affiliation":[{"name":"Chemistry of Medicinal Plants Department, National Research Centre, 33 El Bohouth St. (Former El Tahrirst.), Dokki, P.O. 12622, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-467X","authenticated-orcid":true,"given":"Riaz","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7441","authenticated-orcid":true,"given":"Ali S.","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husseiny A.","family":"Husseiny","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Misr University for Science and Technology (MUST), Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-2942","authenticated-orcid":true,"given":"Alicja","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Environmental Hygiene and Animal Welfare, Wroc\u0142aw University of Environmental and Life Sciences, Che\u0142mo\u0144skiego 38C, Wroc\u0142aw 51-630, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel-Razik H.","family":"Farrag","sequence":"additional","affiliation":[{"name":"Pathology Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, P.O. 12622, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"839","article-title":"Antimicrobial activity of some important medicinal plant against plant and human pathogens","volume":"4","author":"B. 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