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The damage caused by heat stress to animals has been more and more significant as the worldwide climate continues to rise, along with the breeding industry\u2019s expanding scale and stocking density, and it has become the most important stress\u2010causing factor in southern China. In this review, we described the effects of heat stress on animal immune organs and immune system. The much\u2010debated topic is how hyperthermia affects the tight junction barrier. Heat stress also induces inflammation in the body of animals causing low body weight and loss of appetite. This review also discussed that heat stress leads to hepatic disorder, and it also damages the intestine. The small intestine experiences ischemia, and the permeability of the intestine increases. Furthermore, the oxidative stress and mitogen\u2010activated protein kinase (MAPK) pathways have a significant role in stress\u2010induced cellular and organ injury. The study has shown that MAPK activity in the small intestine was increased by heat stress. Heat stress caused extreme small intestine damage, enhanced oxidative stress, and activated MAPK signaling pathways.<\/jats:p>","DOI":"10.1155\/2022\/8547379","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T13:05:11Z","timestamp":1662037511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Influence of Heat Stress on Intestinal Epithelial Barrier Function, Tight Junction Protein, and Immune and Reproductive Physiology"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-5497","authenticated-orcid":false,"given":"Sahar","family":"Ghulam Mohyuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-4042","authenticated-orcid":false,"given":"Imran","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-7382","authenticated-orcid":false,"given":"Ahmad","family":"Zada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-1386","authenticated-orcid":false,"given":"Aftab","family":"Qamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-2859","authenticated-orcid":false,"given":"Abdelaziz Adam Idriss","family":"Arbab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-8577","authenticated-orcid":false,"given":"Xin-bing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-9191","authenticated-orcid":false,"given":"Zhi-chao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-5221","authenticated-orcid":false,"given":"Xiao-Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-3804","authenticated-orcid":false,"given":"Yan-Hong","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-484X","authenticated-orcid":false,"given":"Xiang Hong","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-8447","authenticated-orcid":false,"given":"Yang","family":"Zhang-Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-7172","authenticated-orcid":false,"given":"Mao","family":"Yong Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.2.237"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102204"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(01)00500-1"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03252"},{"key":"e_1_2_7_5_2","article-title":"Biochemica and physiological changes during thermal stress in bovines","volume":"4","author":"Dudhatra G. 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