{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:49:48Z","timestamp":1791434988540,"version":"4.3.3"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":198,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV radiation\u2010induced damage repair that is characterized by photosensitivity and a propensity for developing, among many others, skin cancers at an early age. This systematic review focused on the correlation between the clinical, pathological, and genetic aspects of XP and skin cancer.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A systematic review was conducted through a literature search of online databases PubMed, Cochrane Library, SciELO, and Google Scholar. Search terms were \u201cXeroderma pigmentosum\u201d, \u201cXP\u201d, \u201cXPC\u201d, \u201cNucleotide excision repair\u201d, \u201cNER\u201d, \u201cPOLH\u201d, \u201cDry pigmented skin\u201d, and \u201cUV sensitive syndrome\u201d meshed with the terms \u201cSkin cancer\u201d, \u201cMelanoma\u201d, and \u201cNMSC\u201d.\n                    <jats:italic>Results.<\/jats:italic>\n                    After 504 abstracts screening, 13 full\u2010text articles were assessed for eligibility, and 3 of them were excluded. Ten articles were selected for qualitative assessment.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Patients with XP usually suffer shorter lives due to skin cancer and neurodegenerative disease. Deletion\/alteration of a distinct gene allele can produce different types of cancer. The XPC and XP\u2010E variants are more likely to have skin cancer than patients in other complement groups, and the most common cause of death for these patients is skin cancer (metastatic melanoma or invasive SCC). Still, aggressive preventative measures to minimize UV radiation exposure can retard the course of the disease and improve the quality of life.\n                  <\/jats:p>","DOI":"10.1155\/2022\/8549532","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T19:20:06Z","timestamp":1658172006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Xeroderma Pigmentosum: A Genetic Condition Skin Cancer Correlated\u2014A Systematic Review"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-9660","authenticated-orcid":false,"given":"Tito","family":"Brambullo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-4066","authenticated-orcid":false,"given":"Michele Rosario","family":"Colonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Vindigni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-4733","authenticated-orcid":false,"given":"Stefano","family":"Piaserico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-9248","authenticated-orcid":false,"given":"Giuseppe","family":"Masciopinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-7485","authenticated-orcid":false,"given":"Mariarosaria","family":"Galeano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-4278","authenticated-orcid":false,"given":"Alfio Luca","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-8252","authenticated-orcid":false,"given":"Franco","family":"Bassetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gdata.2015.07.008"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26391"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-2-221"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.01.014"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.06.010"},{"key":"e_1_2_12_6_2","first-page":"760","article-title":"Xeroderma pigmentosum. cutaneous, ocular, and neurologic abnormalities in 49 Tunisian cases","volume":"83","author":"Zghal M.","year":"2005","journal-title":"La Tunisie M\u00e9dicale"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2019.108286"},{"key":"e_1_2_12_8_2","first-page":"245","volume-title":"The Genetic Basis of Human Cancer","author":"Bootsma D.","year":"1998"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/256245"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101448"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.083022"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660260111026"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.4.1984"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0616-2"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160715985"},{"key":"e_1_2_12_16_2","article-title":"PRISMA Group. 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